Results 41 to 50 of about 1,575,835 (313)

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Institutional Determinants of Stock Market Development in European Union Transition Economies

open access: yesRomanian Economic Journal, 2016
Stock markets have become an important market for long run fund flows between savers and investors and also a determinant of economic growth with the emergence of endogenous growth theories. This study investigates the impact of institutional development
Yilmaz Bayar
doaj  

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

Corrupção Burocrática e Empreendedorismo: Uma Análise Empírica dos Estados Brasileiros [PDF]

open access: yesRAC: Revista de Administração Contemporânea, 2015
Entrepreneurial activity performs an important role in a nation’s economic dynamics. Previous studies argue that institutional factors are correlated with the opening of new businesses, however, the literature is divergent as to the effect of ...
Felipe Luiz Neves Bezerra de Melo   +2 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

How important is the scientific knowledge gap between leading research and producing countries of lithium?

open access: yesHeliyon
: The strong increase in global demand for lithium, driven by the ion battery market and the use of this non-metallic mineral in various economic sectors such as mining (as a non-metallic and non-renewable mineral), health, technology, and geopolitical ...
Cristian Colther   +2 more
doaj   +1 more source

Impact of foreign direct investment on the exports of five major sectors of Pakistan’s economy: A governance perspective

open access: yesChinese Journal of Population, Resources and Environment, 2023
This study investigates and analyses empirically the impact of Foreign Direct Investment (FDI) inflows on the exports for a panel series of five large-scale manufacturing industries of Pakistan during the period 2000-2020.
Kamran Farid   +3 more
doaj   +1 more source

Predictive Regressions with Panel Data [PDF]

open access: yesSSRN Electronic Journal, 2006
This paper analyzes panel data inference in predictive regressions with endogenous and nearly persistent regressors. The standard fixed effects estimator is shown to suffer from a second order bias; analytical results, as well as Monte Carlo evidence, show that the bias and resulting size distortions can be severe.
openaire   +3 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Real time Data Acquisition of Solar Panel

open access: yesInternational Journal of Energetica, 2022
We created a real-time acquisition system to track the voltage, current and temperature changes of the solar panel as we installed it in a charging regulator with a battery.
Youssef Rehouma   +4 more
doaj  

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