Results 171 to 180 of about 304,080 (307)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

First series : 1:50 000 map /

open access: yes, 1978
Relief shown by contours, gradient tints, hachures, and spot heights.; Panel title.; Each sheet individually titled and numbered.; Geographic coverage complete in 29 sheets.; Irish grid.; Includes location map, index map, and col ...
Ordnance Survey of Northern Ireland.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Questionnaire for the panel survey

open access: yes
Questionnaire for the retrieval of panel survey data including questions measuring the norms, values, attitudes, expectations, and behaviors of young people regarding democracy, power, politics, policy-making as well as social and political participation (online and offline) and the organization of economic, social and private life, and also questions ...
openaire   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Secure Livelihoods Research Consortium Panel Survey, 2012-2018

open access: yes, 2017
copyright UK Data Service and data collection copyright owner.The Secure Livelihoods Research Consortium Panel Survey, 2012-2018 is a three-wave individual panel survey (2012/13, 2015 and 2018) conducted in three countries, and two-wave individual ...
Overseas Development Institute
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

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