Paneth Cell Carcinoma of the Stomach [PDF]
The Korean Journal of Gastroenterology, 2022 Paneth cell carcinoma is a rare carcinoma composed predominantly or purely of malignant Paneth cells. An 83-year-old woman presented for evaluation of an elevated lesion in the stomach.
Jun Wan Kim, Gwang Ha Kim, Kyung Bin Kim
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Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis. [PDF]
PLoS ONE, 2018 Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal morbidity and mortality in premature infants. Human and animal studies suggest a role for Paneth cells in NEC pathogenesis.
Shiloh R Lueschow +11 more
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From birth to death: The hardworking life of Paneth cell in the small intestine [PDF]
Frontiers in Immunology, 2023 Paneth cells are a group of unique intestinal epithelial cells, and they play an important role in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as Wnt, Notch, and BMP signaling, affect the differentiation of ...
Chenbin Cui +5 more
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PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in MiceSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC) barrier maintenance, IEC–macrophage ...
Vinicius Canale +15 more
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Generation of a new Paneth cell–specific Cre-recombinase transgenic mouse line [PDF]
Frontiers in ImmunologyPaneth cells are located in the crypts of Lieberkühn in mammalian small intestines and are producing antimicrobial peptides to keep the microbiome under control.
Natalia Garcia-Gonzalez +20 more
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Paneth cell ontogeny in term and preterm ovine models [PDF]
Frontiers in Veterinary ScienceIntroductionPaneth cells are critically important to intestinal health, including protecting intestinal stem cells, shaping the intestinal microbiome, and regulating host immunity.
Geoanna M. Bautista +8 more
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IFN-γ mediates Paneth cell death via suppression of mTOR [PDF]
eLife, 2021 Paneth cells constitutively produce antimicrobial peptides and growth factors that allow for intestinal homeostasis, host protection, and intestinal stem cell replication.
Alessandra Araujo +8 more
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Regulation of Paneth Cell Function by RNA-Binding Proteins and Noncoding RNAs [PDF]
Cells, 2021 Paneth cells are specialized intestinal epithelial cells that are located at the base of small intestinal crypts and play a vital role in preserving the gut epithelium homeostasis.
Hee K. Chung +3 more
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Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties [PDF]
eLifeMetastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear.
Jae Hun Shin +11 more
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Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples [PDF]
Scientific ReportsThe Paneth cell, a secretory cell of the small intestine, expresses numerous host defense proteins, and is hypothesized to play an important role in host defense against infection.
Gill Diamond +19 more
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