Results 101 to 110 of about 29,116 (211)

The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track

Advanced Science, Volume 13, Issue 1, 5 January 2026.
In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang, Minghao Zhang, Qingbo Zheng, Qinran Yu, Guowu Yang, Wenwen Ren, Xiaoming Ma, Yongfu La, Pengjia Bao, Min Chu, Xian Guo, Chunnian Liang, Ping Yan   +12 more
wiley   +1 more source

The mucosal cellular response to infection with Ancylostoma ceylanicum [PDF]

, 2008
Although hookworms are known to stimulate inflammatory responses in the intestinal mucosa of their hosts, there is little quantitative data on this aspect of infection.
Aziz, Behnke, Dehlawi, Elliott, Else, Gibbs, Ishikawa, J.M. Behnke, L.M.M. Alkazmi, M.S. Dehlawi, Pennock   +10 more
core   +2 more sources

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Disease Models & Mechanisms, 2019
Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive ...
Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J. M. Watson, Simon R. Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P. Powell, Isabelle Hautefort, Tom Wileman, Tamas Korcsmaros   +19 more
doaj   +1 more source

Endoplasmic Reticulum Stress, Unfolded Protein Response and Altered T Cell Differentiation in Necrotizing Enterocolitis [PDF]

, 2013
Background:Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) play important roles in chronic intestinal inflammation.
Bruijn, A.C.J.M. (Adrianus) de, Goudoever, J.B. (Hans) van, Korteland-van Male, A.M. (Anita), Lu, P. (Peng), Mei, S. (Shan), Renes, I.B. (Ingrid), Struijs, A.E.C.J.M. (Marie-Chantal), Witte-Bouma, J. (Janneke)   +7 more
core   +1 more source

Paneth cells [PDF]

Current Biology, 2014
van Es, Johan H, Clevers, Hans
openaire   +2 more sources

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress [PDF]

, 2017
Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium.
Kraft, Crystal, Lynch, John P., Pattison, Amanda M., Rappaport, Jeff A., Snook, Adam E., Waldman, Scott A.   +5 more
core   +2 more sources

Intestinal dysbiosis and innate immune responses in axial spondyloarthritis [PDF]

, 2016
Purpose of review Inflammatory innate and adaptive immune cell responses to commensal bacteria underlie the pathogenesis of human chronic inflammatory diseases. Intestinal dysbiosis has been described in patients with spondyloarthritis (SpA) and seems to
Ciccia, F., Ferrante, A., Triolo, G.
core   +1 more source

Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation

Gut Microbes, 2020
Although the oral administration of Bifidobacterium longum (B. longum) relieves the signs of irritable bowel syndrome (IBS) in clinical settings, the mechanisms underlying its effects are unclear.
Chunhua Zhou, Xue Fang, Jiajia Xu, Jun Gao, Ling Zhang, Jiulong Zhao, Yuting Meng, Wei Zhou, Xu Han, Yu Bai, Zhaoshen Li, Duowu Zou   +11 more
doaj   +1 more source

Best of United European Gastroenterology Week 2025

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
Iuliana Nenu, Sara Nikolic, Eduardo Valdivielso, Giovanni Marasco   +3 more
wiley   +1 more source

Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice

Disease Models & Mechanisms, 2012
SUMMARY Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants. During NEC pathogenesis, bacteria are able to penetrate innate immune defenses and invade the intestinal epithelial layer, causing subsequent ...
Chunxian Zhang, Michael P. Sherman, Lawrence S. Prince, David Bader, Jörn-Hendrik Weitkamp, James C. Slaughter, Steven J. McElroy   +6 more
doaj   +1 more source