An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. [PDF]
, 2014 Intestinal crypt fission is a homeostatic phenomenon, observable in healthy adult mucosa, but which also plays a pathological role as the main mode of growth of some intestinal polyps.
A. Patrick Gunning +69 more
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Paneth Cells in Colonic Adenomas: Association with Higher Adenoma Burden
Philippine Journal of Pathology, 2016 Introduction. The association of Paneth cells with colorectal neoplasms has been demonstrated in several studies and case reports. The frequency of Paneth cell-containing adenomas ranges from 0.2 to 39% in the various published studies.
Rex Michael Santiago, Glenda Lyn Pua
doaj +1 more source
mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake [PDF]
, 2012 How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to ...
Abdulmetin Dursun +45 more
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Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn’s Disease
Cells, 2021 Paneth cell defects in Crohn’s disease (CD) patients (called the Type I phenotype) are associated with worse clinical outcomes. Recent studies have implicated mitochondrial dysfunction in Paneth cells as a mediator of ileitis in mice.
Kibrom M. Alula +10 more
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Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. [PDF]
, 2016 Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed.
Cai, Linbi +19 more
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Journal of Clinical Pathology, 1968 A villous papilloma of the colon showing neoplastic proliferation of Paneth cells is described. The literature is reviewed and only three other tumours are accepted as showing neoplastic proliferation of Paneth cells.
openaire +2 more sources
Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]
, 2018 Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
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Paneth Cells during Viral Infection and Pathogenesis
Viruses, 2018 Paneth cells are major secretory cells located in the crypts of Lieberkühn in the small intestine. Our understanding of the diverse roles that Paneth cells play in homeostasis and disease has grown substantially since their discovery over a hundred ...
Mayumi K. Holly, Jason G. Smith
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LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
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Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
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