Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
core +1 more source
Paneth cells in farm animals: current status and future direction
Journal of Animal Science and Biotechnology, 2023 A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their regulation of intestinal microbiota and intestinal stem cells (ISCs).
Chenbin Cui +7 more
doaj +1 more source
Proteomic Profiling of Enteroid Cultures Skewed Towards Development of Specific Epithelial Lineages [PDF]
, 2018 Recently, three‐dimensional small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic ...
Aoki-Yoshida +28 more
core +5 more sources
Frontiers in Immunology, 2020 Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6.
Kiminori Nakamura +9 more
doaj +1 more source
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition. [PDF]
PLoS ONE, 2012 Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear.
Ajay S Gulati +8 more
doaj +1 more source
Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]
, 2014 Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana +12 more
core +3 more sources
Intrauterine Growth Restriction Alters Mouse Intestinal Architecture during Development. [PDF]
PLoS ONE, 2016 Infants with intrauterine growth restriction (IUGR) are at increased risk for neonatal and lifelong morbidities affecting multiple organ systems including the intestinal tract.
Camille M Fung +6 more
doaj +1 more source
Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome [PDF]
, 2019 We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome (“dysbiosis”) in a patient cohort.
Ciorba, Matthew A +13 more
core +3 more sources
Mist1 Expression Is Required for Paneth Cell MaturationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2019 Background: Paneth cells are professional secretory cells found within the small intestinal crypt epithelium. Although their role as part of the innate immune complex providing antimicrobial secretory products is well-known, the mechanisms that control ...
Christopher M. Dekaney +3 more
doaj +1 more source
Intestinal macromolecular transport supporting adaptive immunity [PDF]
, 2019 The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core +2 more sources