Results 41 to 50 of about 29,116 (211)

Paneth cells as a site of origin for intestinal inflammation. [PDF]

, 2013
The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) activity, causes Paneth
A Bertolotti, A Kaser, A Kaser, B Levine, BB Madison, DR Shimshek, E Tashiro, EH Carchman, EM Garabedian, F Urano, F Zhao, G Rogler, I Novoa, J Hampe, J Wehkamp, JC Barrett, JD Rioux, JW Pierce, K Cadwell, K Cadwell, K Vidal, KJ Maloy, KM Rouschop, KS Kobayashi, L Baert, L Bry, L Jostins, L Yang, M Boyce, M Kaneko, M Komatsu, M Parkes, N Fujita, N Fujita, N Mizushima, N Mizushima, P Hu, P Kuballa, S Sarkar, S Srinivas, S Vaishnava, SL Hempel, SS Cao, T Iwawaki, T Sato, X Tréton, Y Satoh, Y Wei   +47 more
core   +3 more sources

Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary

Cellular and Molecular Gastroenterology and Hepatology
Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of
Michaela Quintero, Linda C. Samuelson
doaj   +1 more source

Paneth cells as the cornerstones of intestinal and organismal health: a primer

EMBO Molecular Medicine, 2022
Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis.
Charlotte Wallaeys, Natalia Garcia‐Gonzalez, Claude Libert   +2 more
doaj   +1 more source

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"? [PDF]

, 2006
The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved.
Fischer, Simon, Gál, István, Lakatos, László, Lakatos, Péter László, Papp, János   +4 more
core   +1 more source

Paneth cells and necrotizing enterocolitis [PDF]

Gut Microbes, 2012
Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the ...
openaire   +2 more sources

Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell HomeostasisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Intestinal epithelial homeostasis is maintained by active-cycling and slow-cycling stem cells confined within an instructive crypt-based niche.
Nicholas R. Smith, Paige S. Davies, Trevor G. Levin, Alexandra C. Gallagher, Douglas R. Keene, Sidharth K. Sengupta, Nikki Wieghard, Edward El Rassi, Melissa H. Wong   +8 more
doaj   +1 more source

Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients With Intestinal Failure. [PDF]

, 2016
: Intestinal failure is a rare life-threatening condition that results in the inability to maintain normal growth and hydration status by enteral nutrition alone.
Dunn, James CY, Hong, Sung Noh, Martín, Martín G, Stelzner, Matthias   +3 more
core   +1 more source

Paneth cells: histochemical and morphometric study in control and Solanum glaucophyllum intoxicated rabbits

European Journal of Histochemistry, 2009
The intestinal epithelium has a critical roll in host defence. One specialised cell type involved in this function is the Paneth cell, which secretes many substances with antimicrobial properties in response to different stimuli.
CN Zanuzzi, PA Fontana, CG Barbeito, EL Portiansky, EJ Gimeno   +4 more
doaj   +1 more source

A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells.

PLoS ONE, 2022
HNF4α has been implicated in IBD through a number of genome-wide association studies. Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT).
Seung-Hee Lee, Vimal Veeriah, Fred Levine   +2 more
doaj   +1 more source

The Paneth cell in disease [PDF]

Gut, 1969
A systematic study of the distribution of Paneth cells in disease of the small and large intestine is described. In disease of the small intestine and appendix there is usually a fall in the number of Paneth cells normally present. Occasionally, as in Crohn's disease, there may be proliferation.
openaire   +2 more sources