Results 81 to 90 of about 29,116 (211)

An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease

Frontiers in Immunology, 2020
The Paneth cells reside in the small intestine at the bottom of the crypts of Lieberkühn, intermingled with stem cells, and provide a niche for their neighbors by secreting growth and Wnt-factors as well as different antimicrobial peptides including ...
Jan Wehkamp, Eduard F. Stange
doaj   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

A Paneth cell surrogate? [PDF]

Gut, 2002
We read with interest the article by Cunliffe et al ( Gut 2001; 48 :176–85) on defensin 5 stored in normal Paneth cells and in metaplastic Paneth cells in inflammatory bowel disease (IBD). In recent years a great deal of interest has centred around Paneth cells as carriers of innate host defence, effective through their content of antimicrobial ...
openaire   +1 more source

Insufficient Expression of the Autophagic Protein ATG16L1 Results in Accelerated Carcinogenesis Related to an Aberrant B Cell Response

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Autophagy‐related proteins (ATGs) regulate a great variety of cellular responses beyond autophagy. In cancer, the role of ATG proteins is central, as evidenced in spontaneous cancer emerging in animals lacking ATG proteins. Aim To determine whether ATG16L1 may be participating in tumorigenesis in colonic and oral mucosa and its ...
Daniela Mendiola, Betsaida Ortiz, Oscar Nieto, Marisol I. González, Danielle Vannan, Bertus Eksteen, Alejandro Martínez, Diego Mateos, Mónica G. Mendoza‐Rodríguez, Miriam Rodríguez‐Sosa, Luis I. Terrazas, José L. Reyes   +11 more
wiley   +1 more source

Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia. [PDF]

, 2017
A pandemic of metabolic diseases, consisting of type 2 diabetes, nonalcoholic fatty liver disease, and obesity, has imposed critical challenges for societies worldwide, prompting investigation of underlying mechanisms and exploration of low-cost and ...
Bai, Li, Chen, Jingjing, Chen, Zishou, Duan, Yixiang, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Ju, Zhongyuan, Li, Wenwen, Li, Yan, Liu, Yong, Luo, Mei, Pandol, Stephen J, Su, Danmei, Sun, Qun, Wu, Pengfei, Xiao, Zhixiong, Zeng, Yilan, Zhang, Li, Zhang, Xiaohui, Zheng, Han, Zheng, Sujun, Zhu, Airu   +22 more
core   +1 more source

Beyond bacterial defences: the role of lysozyme in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang, Qian Dong, Fuchu He, Zhiwen Gu, Aihua Sun   +4 more
wiley   +1 more source

Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]

, 2002
Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core   +1 more source

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation [PDF]

, 2018
The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling ...
Brauer, Patrick M., Cairns, Robert, Chio, Iok In Christine, Clevers, Hans, Cox, Maureen A., Dominguez-Brauer, Carmen, Elia, Andrew J., Fortin, Jérôme M., Haight, Jillian, Hao, Zhenyue, Inoue, Satoshi, Mak, Tak W., Mana, Miyeko, Marques, Ana, Nechanitzky, Robert, Pollett, Aaron, Reardon, Colin, Sabatini, David, Sato, Toshiro, Sheng, Yi, Silvester, Jennifer, Tworzyanski, Leanne, van Es, Johan H., Wakeham, Andrew, Yilmaz, Omer   +24 more
core   +1 more source

Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Whey proteins possess antimicrobial and prebiotic properties that modulate gut microbiota by promoting beneficial bacteria like Bifidobacterium while suppressing pathogens. This modulation enhances short‐chain fatty acid production and strengthens intestinal barrier integrity, potentially alleviating dysbiosis‐related conditions such as colitis and ...
Tolulope Joshua Ashaolu, Chi‐Ching Lee, Ozgur Tarhan, Ali Rashidinejad, Seid Mahdi Jafari   +4 more
wiley   +1 more source

Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι

Cell Reports, 2016
Paneth cells are a highly specialized population of intestinal epithelial cells located in the crypt adjacent to Lgr5+ stem cells, from which they differentiate through a process that requires downregulation of the Notch pathway.
Yuki Nakanishi, Miguel Reina-Campos, Naoko Nakanishi, Victoria Llado, Lisa Elmen, Scott Peterson, Alex Campos, Surya K. De, Michael Leitges, Hiroki Ikeuchi, Maurizio Pellecchia, Richard S. Blumberg, Maria T. Diaz-Meco, Jorge Moscat   +13 more
doaj   +1 more source