Paneth cells in farm animals: current status and future direction [PDF]
Journal of Animal Science and Biotechnology, 2023 A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their regulation of intestinal microbiota and intestinal stem cells (ISCs).
Chenbin Cui +7 more
doaj +2 more sources
Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis. [PDF]
PLoS ONE, 2018 Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal morbidity and mortality in premature infants. Human and animal studies suggest a role for Paneth cells in NEC pathogenesis.
Shiloh R Lueschow +11 more
doaj +4 more sources
Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis [PDF]
Cells, 2021 Background: Previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation.
Erika López-Arribillaga +8 more
doaj +2 more sources
Paneth cells as the cornerstones of intestinal and organismal health: a primer [PDF]
EMBO Molecular Medicine, 2022 Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis.
Charlotte Wallaeys +2 more
doaj +2 more sources
Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyIntestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of
Michaela Quintero, Linda C. Samuelson
doaj +2 more sources
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake [PDF]
Nature, 2012 How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to ...
Pekka Katajisto +2 more
exaly +4 more sources
Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation [PDF]
Frontiers in Physiology, 2020 Paneth cells are residents of the intestinal epithelium. Abnormal appearance of Paneth cells has been widely documented in non-intestinal tissues within the digestive tract and even observed in non-gastrointestinal organs.
Rajbir Singh +7 more
doaj +2 more sources
Isolation and Co-culture of Paneth Cells and Intestinal Stem Cells [PDF]
Bio-ProtocolCrypts at the base of intestinal villi contain intestinal stem cells (ISCs) and Paneth cells, the latter of which work as niche cells for ISCs. When isolated and cultured in the presence of specific growth factors, crypts give rise to self-renewing 3D ...
Ryosuke Isotani +3 more
doaj +2 more sources
Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse [PDF]
Frontiers in Immunology, 2020 Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6.
Kiminori Nakamura +9 more
doaj +2 more sources
Paneth Cells during Viral Infection and Pathogenesis [PDF]
Viruses, 2018 Paneth cells are major secretory cells located in the crypts of Lieberkühn in the small intestine. Our understanding of the diverse roles that Paneth cells play in homeostasis and disease has grown substantially since their discovery over a hundred ...
Mayumi K. Holly, Jason G. Smith
doaj +2 more sources