Results 91 to 100 of about 28,981 (212)

Immunofluorescent Staining of Mouse Intestinal Stem Cells

Bio-Protocol, 2016
Immunofluorescent staining of organoids can be performed to visualize molecular markers of cell behavior. For example, cell proliferation marked by incorporation of nucleotide (EdU), or to observe markers of intestinal differentiation including paneth ...
Kevin O’Rourke, Lukas Dow, Scott Lowe
doaj   +1 more source

Infectious agents and inflammation. The role of microbiota in autoimmune arthritis [PDF]

, 2018
In higher vertebrates, mucosal sites at the border between the internal and external environments, directly interact with bacteria, viruses, and fungi.
D'Amelio, Raffaele, Picchianti-Diamanti, Andrea, Rosado, Maria M.   +2 more
core   +2 more sources

Histopathological Findings of Appendix Specimens in Quiescent Ulcerative Colitis: Correlations With Clinical Outcomes in the ACCURE Trial

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background The ACCURE trial demonstrated that appendicectomy reduces relapse rates within 1 year in patients with ulcerative colitis (UC) in remission. We aimed to explore appendiceal histopathology in quiescent UC and assess its association with postoperative relapse. Methods Appendix specimens from Dutch participants in the ACCURE trial were
Eva Visser, Demy Danielsson, Lianne Heuthorst, Geert R. D'Haens, Willem A. Bemelman, Christianne J. Buskens, Aart Mookhoek   +6 more
wiley   +1 more source

Intestinal dysbiosis and innate immune responses in axial spondyloarthritis [PDF]

, 2016
Purpose of review Inflammatory innate and adaptive immune cell responses to commensal bacteria underlie the pathogenesis of human chronic inflammatory diseases. Intestinal dysbiosis has been described in patients with spondyloarthritis (SpA) and seems to
Ciccia, F., Ferrante, A., Triolo, G.
core   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

eLife
Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear.
Jae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K Dinesh, Stephen E Maher, Jeonghyun Kim, Soyeon Park, Jun Young Hong, John Wysolmerski, Jungmin Choi, Alfred LM Bothwell   +11 more
doaj   +1 more source

Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice

Disease Models & Mechanisms, 2012
SUMMARY Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants. During NEC pathogenesis, bacteria are able to penetrate innate immune defenses and invade the intestinal epithelial layer, causing subsequent ...
Chunxian Zhang, Michael P. Sherman, Lawrence S. Prince, David Bader, Jörn-Hendrik Weitkamp, James C. Slaughter, Steven J. McElroy   +6 more
doaj   +1 more source

The mucosal cellular response to infection with Ancylostoma ceylanicum [PDF]

, 2008
Although hookworms are known to stimulate inflammatory responses in the intestinal mucosa of their hosts, there is little quantitative data on this aspect of infection.
Aziz, Behnke, Dehlawi, Elliott, Else, Gibbs, Ishikawa, J.M. Behnke, L.M.M. Alkazmi, M.S. Dehlawi, Pennock   +10 more
core   +2 more sources

The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track

Advanced Science, Volume 13, Issue 1, 5 January 2026.
In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang, Minghao Zhang, Qingbo Zheng, Qinran Yu, Guowu Yang, Wenwen Ren, Xiaoming Ma, Yongfu La, Pengjia Bao, Min Chu, Xian Guo, Chunnian Liang, Ping Yan   +12 more
wiley   +1 more source

Endoplasmic Reticulum Stress, Unfolded Protein Response and Altered T Cell Differentiation in Necrotizing Enterocolitis [PDF]

, 2013
Background:Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) play important roles in chronic intestinal inflammation.
Bruijn, A.C.J.M. (Adrianus) de, Goudoever, J.B. (Hans) van, Korteland-van Male, A.M. (Anita), Lu, P. (Peng), Mei, S. (Shan), Renes, I.B. (Ingrid), Struijs, A.E.C.J.M. (Marie-Chantal), Witte-Bouma, J. (Janneke)   +7 more
core   +1 more source