Results 111 to 120 of about 28,981 (212)

Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell HomeostasisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Intestinal epithelial homeostasis is maintained by active-cycling and slow-cycling stem cells confined within an instructive crypt-based niche.
Nicholas R. Smith, Paige S. Davies, Trevor G. Levin, Alexandra C. Gallagher, Douglas R. Keene, Sidharth K. Sengupta, Nikki Wieghard, Edward El Rassi, Melissa H. Wong   +8 more
doaj   +1 more source

Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses

Stem Cell Research & Therapy
Background The canonical Wnt signaling pathway controls the continuous renewal of the intestinal epithelium and the specification of epithelial cell lineages. Tcf4, a nuclear mediator of Wnt signaling, is essential for the differentiation and maintenance
Lucie Janeckova, Monika Stastna, Dusan Hrckulak, Linda Berkova, Jan Kubovciak, Jakub Onhajzer, Vitezslav Kriz, Stela Dostalikova, Tereza Mullerova, Katerina Vecerkova, Marketa Tenglerova, Stepan Coufal, Klara Kostovcikova, Richard S. Blumberg, Dominik Filipp, Konrad Basler, Tomas Valenta, Michal Kolar, Vladimir Korinek   +18 more
doaj   +1 more source

Paneth Cells Are a Constitutive Source of IL-10 in Mouse Small Intestinal Organoids

Organoids
The healthy gut masks a dynamic balance between pro- and anti-inflammatory activities, largely due to microbial factors in the lumen. IL-10 is vital among the anti-inflammatory mediators, yet confirming constitutive versus stimulated secretion in any ...
Huong Nguyen, Francesca Di Cara, Jun Wang, Andrew W. Stadnyk   +3 more
doaj   +1 more source

Myeloid vitamin D receptor regulates Paneth cells and microbial homeostasis. [PDF]

FASEB J, 2023
Bakke DS, Zhang J, Zhang Y, Ogbu D, Xia Y, Sun J.   +5 more
europepmc   +1 more source

Research progress on the relationship between Paneth cells-susceptibility genes, intestinal microecology and inflammatory bowel disease. [PDF]

World J Clin Cases, 2023
Zhou QM, Zheng L.
europepmc   +1 more source

Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy

Communications Biology
A recent single-cell survey of the small-intestinal epithelium suggests that mucosal pentraxin 2 (Mptx2) is a new Paneth cell marker, but its function and involved mechanism in the Paneth cell are still unknown. Therefore, we create Mptx2 knockout (Mptx2
Weihui Yan, Shanshan Chen, Ying Wang, Yaying You, Ying Lu, Weipeng Wang, Bo Wu, Jun Du, Shicheng Peng, Wei Cai, Yongtao Xiao   +10 more
doaj   +1 more source

DeMISTifying Paneth Cell Maturation [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2019
Spatz, Lillian B., Mills, Jason C.
openaire   +2 more sources

Paneth-like cells produced from OLFM4+ stem cells support OLFM4+ stem cell growth in advanced colorectal cancer

Communications Biology
Tumor tissues consist of heterogeneous cells that originate from stem cells; however, their cell fate determination program remains incompletely understood.
Mizuho Sakahara, Takuya Okamoto, Upasna Srivastava, Yasuko Natsume, Hitomi Yamanaka, Yutaka Suzuki, Kazutaka Obama, Satoshi Nagayama, Ryoji Yao   +8 more
doaj   +1 more source

Multifaceted involvements of Paneth cells in various diseases within intestine and systemically. [PDF]

Front Immunol, 2023
Cui C, Wang X, Li L, Wei H, Peng J.
europepmc   +1 more source

Outlook Magazine, Winter 2018 [PDF]

, 2018
https://digitalcommons.wustl.edu/outlook/1206/thumbnail ...

core   +1 more source