Paneth cells as a site of origin for intestinal inflammation [PDF]
Nature, 2013 The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) activity, causes Paneth
Eduardo Martinez-Naves +2 more
exaly +5 more sources
FABP4 in Paneth cells regulates antimicrobial protein expression to reprogram gut microbiota [PDF]
Gut Microbes, 2022 Antimicrobial proteins possess a broad spectrum of bactericidal activity and play an important role in shaping the composition of gut microbiota, which is related to multiple diseases such as metabolic syndrome.
Xiaomin Su +10 more
doaj +2 more sources
Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding [PDF]
JCI Insight, 2020 High-fat feeding (HFF) leads to gut dysbiosis through unclear mechanisms. We hypothesize that bile acids secreted in response to high-fat diets (HFDs) may act on intestinal Paneth cells, leading to gut dysbiosis.
Hui Zhou +8 more
doaj +2 more sources
Paneth Cell Carcinoma of the Stomach
The Korean Journal of Gastroenterology, 2022 Paneth cell carcinoma is a rare carcinoma composed predominantly or purely of malignant Paneth cells. An 83-year-old woman presented for evaluation of an elevated lesion in the stomach.
Jun Wan Kim, Gwang Ha Kim, Kyung Bin Kim
doaj +3 more sources
Secretory autophagy of lysozyme in Paneth cells. [PDF]
Autophagy, 2018 Secretion of antimicrobial proteins is an important host defense mechanism against bacteria, yet how secretory cells maintain function during bacterial invasion has been unclear. We discovered that Paneth cells, specialized secretory cells in the small intestine, react to bacterial invasion by rerouting a critical secreted antibacterial protein through
Bel S, Hooper LV.
europepmc +4 more sources
Paneth cells in intestinal physiology and pathophysiology. [PDF]
World J Gastrointest Pathophysiol, 2017 Small intestinal mucosa is characterised by villus forming connective tissues with highly specialised surface lining epithelial cells essentially contributing to the establishment of the intestinal border. In order to perform these diverse functions, spatially distinct compartments of epithelial differentiation are found along the crypt-villus axis ...
Gassler N.
europepmc +3 more sources
From birth to death: The hardworking life of Paneth cell in the small intestine
Frontiers in Immunology, 2023 Paneth cells are a group of unique intestinal epithelial cells, and they play an important role in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as Wnt, Notch, and BMP signaling, affect the differentiation of ...
Chenbin Cui +5 more
doaj +1 more source
Secretory Sorcery: Paneth Cell Control of Intestinal Repair and HomeostasisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2021 Paneth cells are professional secretory cells that classically play a role in the innate immune system by secreting antimicrobial factors into the lumen to control enteric bacteria.
Paul Cray +2 more
doaj +1 more source
Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence [PDF]
Gut, 2020 Eva Rath +2 more
exaly +2 more sources
Regulation of Paneth Cell Function by RNA-Binding Proteins and Noncoding RNAs
Cells, 2021 Paneth cells are specialized intestinal epithelial cells that are located at the base of small intestinal crypts and play a vital role in preserving the gut epithelium homeostasis.
Hee K. Chung +3 more
doaj +1 more source