Journal of Clinical Pathology, 1968 A villous papilloma of the colon showing neoplastic proliferation of Paneth cells is described. The literature is reviewed and only three other tumours are accepted as showing neoplastic proliferation of Paneth cells.
openaire +2 more sources
Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]
, 2018 Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core +2 more sources
IFN-γ mediates Paneth cell death via suppression of mTOR
eLife, 2021 Paneth cells constitutively produce antimicrobial peptides and growth factors that allow for intestinal homeostasis, host protection, and intestinal stem cell replication.
Alessandra Araujo +8 more
doaj +1 more source
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
core +2 more sources
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
core +1 more source
Paneth Cell, Gut Microbiota Dysbiosis and Diabetes Mellitus
Applied Sciences, 2023 Around 500 million adults in the world have diabetes mellitus, and the incidence is increasing. Over 90% of type 2 diabetes mellitus cases are associated with dysbiosis of the microbiota of the gut, chronic systemic inflammation, mitochondrial ...
Thifhelimbilu Luvhengo +4 more
doaj +1 more source
Paneth Cells and Lgr5+ Intestinal Stem Cells in Radiation Enteritis
Applied Sciences, 2023 Cancer is the leading cause of death in adults and majority of cancers involve abdominal and pelvic organs. Radiotherapy is used in the management of around half of patients who have abdominal and pelvic malignancies and 70% of the treated patients will ...
Thifhelimbilu Luvhengo +2 more
doaj +1 more source
Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]
, 2014 Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana +12 more
core +3 more sources
Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium. [PDF]
PLoS ONE, 2014 Afadin is an actin filament-binding protein that acts cooperatively in cell adhesion with the cell adhesion molecule nectin, and in directional cell movement with the small G protein Rap1 in a nectin-independent manner.
Miki Tanaka-Okamoto +6 more
doaj +1 more source