Intestinal macromolecular transport supporting adaptive immunity [PDF]
, 2019 The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
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Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"? [PDF]
, 2006 The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved.
Fischer, Simon +4 more
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Proteomic Profiling of Enteroid Cultures Skewed Towards Development of Specific Epithelial Lineages [PDF]
, 2018 Recently, three‐dimensional small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic ...
Aoki-Yoshida +28 more
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Axin1‘s mystique in manipulating microbiome amidst colitis
Gut Microbes, 2023 Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1’s roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial cells and ...
Shari Garrett, Monica C. Asada, Jun Sun
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The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis [PDF]
, 2017 Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of prematurity. Although the precise cause is not well understood, the main risk factors thought to contribute to NEC include prematurity, formula feeding, and bacterial ...
Bolock, Alexa M +2 more
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Paneth cells and necrotizing enterocolitis [PDF]
Gut Microbes, 2012 Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the ...
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Paneth Cells in Colonic Adenomas: Association with Higher Adenoma Burden
Philippine Journal of Pathology, 2016 Introduction. The association of Paneth cells with colorectal neoplasms has been demonstrated in several studies and case reports. The frequency of Paneth cell-containing adenomas ranges from 0.2 to 39% in the various published studies.
Rex Michael Santiago, Glenda Lyn Pua
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Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients With Intestinal Failure. [PDF]
, 2016 : Intestinal failure is a rare life-threatening condition that results in the inability to maintain normal growth and hydration status by enteral nutrition alone.
Dunn, James CY +3 more
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Mist1 Expression Is Required for Paneth Cell MaturationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2019 Background: Paneth cells are professional secretory cells found within the small intestinal crypt epithelium. Although their role as part of the innate immune complex providing antimicrobial secretory products is well-known, the mechanisms that control ...
Christopher M. Dekaney +3 more
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The Paneth cell in disease [PDF]
Gut, 1969 A systematic study of the distribution of Paneth cells in disease of the small and large intestine is described. In disease of the small intestine and appendix there is usually a fall in the number of Paneth cells normally present. Occasionally, as in Crohn's disease, there may be proliferation.
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