Results 61 to 70 of about 28,981 (212)

Paneth cell ontogeny in term and preterm ovine models

Frontiers in Veterinary Science
IntroductionPaneth cells are critically important to intestinal health, including protecting intestinal stem cells, shaping the intestinal microbiome, and regulating host immunity.
Geoanna M. Bautista, Anjali J. Cera, Rebecca J. Schoenauer, Michele Persiani, Satyan Lakshminrusimha, Praveen Chandrasekharan, Sylvia F Gugino, Mark A. Underwood, Steven J. McElroy   +8 more
doaj   +1 more source

Cytokine tuning of intestinal epithelial function [PDF]

, 2018
The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline, Durum, Scott K., McLean, Mairi H.   +2 more
core   +4 more sources

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Advances in Exploring the Interaction between Paneth Cells and Intestinal Stem Cells and Possible Targets for Traditional Chinese Medicine Based on Mitochondrial Function and Energy Metabolism [PDF]

Zhongguo quanke yixue
Intestinal stem cells and Paneth cells interact with each other to maintain intestinal homeostasis and function, the interaction between intestinal stem cells and Paneth cells is regulated by mitochondria-related functions and energy conversion.
LUO Guoliang, ZHANG Xindan, TANG Taichun, ZHU Yan, WANG Shuting, CHEN Min
doaj   +1 more source

Paneth cell - rich regions separated by a cluster of Lgr5+ cells initiate crypt fission in the intestinal stem cell niche [PDF]

, 2016
The crypts of the intestinal epithelium house the stem cells that ensure the continual renewal of the epithelial cells that line the intestinal tract.
A Durand, A Fatehullah, A Gebhardt, A Humphries, AG Cummins, AJ Ouellette, Alistair J. Langlands, Axel A. Almet, BK Koo, C Metcalfe, C Pin, CM Niessen, CW Tan, E Batlle, E Frijns, E Sancho, EM Garabedian, F Devik, H Cheng, H Cheng, H Ni, HC Clevers, HS Park, HS Park, HS Wasan, Ian P. Newton, Inke S. Näthke, J Dowling, J Holmberg, J Rotolo, J Schindelin, J Totafurno, James M. Osborne, JE Fata, JJ Dehmer, JM de Pereda, JS Thompson, K Martin, KE Wiese, L Bry, L Ritsma, LC Greaves, M Bjerknes, M Bjerknes, ME Berginski, ME Rothenberg, MH Wong, N Barker, N Mandir, NA Wright, NA Wright, NA Wright, Nancy Hynes, NF Shroyer, O Bashir, P Bastide, P Nistico, PA Neumann, Paul L. Appleton, PL Appleton, PS Davies, R van der Neut, RM Clarke, RQ Schaapveld, S Lu, SJ Dunn, SJ Dunn, SL Preston, T Sato, TA Graham, TH Kim, W Guo, WH St Clair, Y Fujimitsu, Y Mori-Akiyama   +74 more
core   +5 more sources

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome [PDF]

, 2019
We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome (“dysbiosis”) in a patient cohort.
Ciorba, Matthew A, Davidson, Nicholas O, Frank, Daniel N, Gathungu, Grace, Li, Ellen, Nelson, Leah M, Robertson, Charles E, Sartor, R. Balfour, Shiekh, Shehzad S, Tian, Xinyu, Wang, Xuefeng, Wolber, Ashley, Zhang, Yuanhao, Zhu, Wei   +13 more
core   +3 more sources

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source