Results 81 to 90 of about 28,981 (212)
Cancer Reports, Volume 9, Issue 2, February 2026.ABSTRACT Background Autophagy‐related proteins (ATGs) regulate a great variety of cellular responses beyond autophagy. In cancer, the role of ATG proteins is central, as evidenced in spontaneous cancer emerging in animals lacking ATG proteins. Aim To determine whether ATG16L1 may be participating in tumorigenesis in colonic and oral mucosa and its ...
Daniela Mendiola +11 more
wiley +1 more source
Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]
, 2002 Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core +1 more source
Micromanagement in the gut : microenvironmental factors govern colon mucosal biofilm structure and functionality [PDF]
, 2015 The human gut microbiome provides us with functional features that we did not have to evolve ourselves and can be viewed as a structured microbial community that operates like a microbial organ within the human host.
De Weirdt, Rosemarie, Van de Wiele, Tom
core +2 more sources
Beyond bacterial defences: the role of lysozyme in cancer
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang +4 more
wiley +1 more source
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease
Frontiers in Immunology, 2020 The Paneth cells reside in the small intestine at the bottom of the crypts of Lieberkühn, intermingled with stem cells, and provide a niche for their neighbors by secreting growth and Wnt-factors as well as different antimicrobial peptides including ...
Jan Wehkamp, Eduard F. Stange
doaj +1 more source
Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Whey proteins possess antimicrobial and prebiotic properties that modulate gut microbiota by promoting beneficial bacteria like Bifidobacterium while suppressing pathogens. This modulation enhances short‐chain fatty acid production and strengthens intestinal barrier integrity, potentially alleviating dysbiosis‐related conditions such as colitis and ...
Tolulope Joshua Ashaolu +4 more
wiley +1 more source
Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition. [PDF]
PLoS ONE, 2012 Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear.
Ajay S Gulati +8 more
doaj +1 more source
Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions
MedComm, Volume 7, Issue 2, February 2026.Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu +4 more
wiley +1 more source
Diagnostic Pathology, 2019 Background Carcinomas composed predominantly or purely of malignant Paneth cells were rarely reported in gastrointestinal system. They have not been reported at gastroesophageal junction nor has the association with Barrett esophagus been explored.
Wenyi Luo +2 more
doaj +1 more source
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation [PDF]
, 2018 The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling ...
Brauer, Patrick M. +24 more
core +1 more source