Results 51 to 60 of about 194,506 (328)

Childhood Internalizing and Externalizing Problems Predict the Onset of Clinical Panic Attacks over Adolescence: The TRAILS Study [PDF]

, 2012
Background: Panic attacks are a source of individual suffering and are an independent risk factor for later psychopathology. However, much less is known about risk factors for the development of panic attacks, particularly during adolescence when the ...
Mathyssek, C.M. (Christina), Olino, T.M. (Thomas), Oort, F.V.A. (Floor) van, Verhulst, F.C. (Frank)   +3 more
core   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Anger: the unrecognized emotion in emotional disorders [PDF]

, 2016
Anger plays a prominent definitional role in some psychological disorders currently widely scattered across DSM‐5 categories (e.g., intermittent explosive disorder, borderline personality disorder).
Barlow, David H., Cassiello-Robbins, Clair   +1 more
core   +1 more source

Learning Optimal Crowd Evacuation from Scratch Through Self‐Play

Advanced Intelligent Systems, EarlyView.
How would a superintelligent crowd behave in emergencies? This study develops an approach using multiagent deep reinforcement learning combined with self‐play to discover optimal evacuation strategies for pressure‐aware agents. The model learns behaviors such as queuing and zipper‐merging that significantly surpass traditional approaches in fatality ...
Mahdi Nasiri, Malte Cordts, Heinz Koeppl, Benno Liebchen   +3 more
wiley   +1 more source

Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats [PDF]

, 2012
Rats with chronic inhibition of GABA synthesis by infusion of l-allyglycine, a glutamic acid decarboxylase inhibitor, into their dorsomedial/perifornical hypothalamus are anxious and exhibit panic-like cardio-respiratory responses to treatment with ...
Engleman, Eric A., Fitz, Stephanie D., Johnson, Philip L., Schkeryantz, Jeffrey M., Shekhar, Anantha, Svensson, Kjell A.   +5 more
core   +1 more source

Parents' WhatsApp coping resources in the context of ongoing political conflicts: An ecological exploration

American Journal of Community Psychology, EarlyView.
Abstract Mobile technologies have become significant resources for crisis communication and social support in recent years. However, despite empirical evidence pointing to the centrality of these technologies for parenthood in everyday life, it is yet unknown how parents' coping resources play a role in the digital environment.
Daphna Yeshua‐Katz, Stav Shapira, Orna Braun‐Lewensohn   +2 more
wiley   +1 more source

Clinical profile and changes in values of mean platelet volume among panic disorder patients

Archives of Mental Health, 2018
Context: The serotonin system is involved in the pathophysiology of anxiety disorders, but it is not practical to measure the serotonin levels inside the brain. Peripheral serotonin activity may reflect the central serotonergic function.
Sanjay Yalamanchili, Sai Kiran Pasupula, Raviteja Chilukuri   +2 more
doaj   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Levels of basophils and eosinophils are elevated while lymphocytes are reduced in patients with panic disorder compared to controls: a preliminary study

Psychiatry and Clinical Psychopharmacology, 2019
OBJECTIVE: This study evaluates total blood count especially white blood cells (WBCs) in patients with panic disorder, based on the possible association between the immunologic system and panic disorder.
Mehmet Gurkan Gurok, Seda Yılmaz, Abdulgani Temizkan, Bilal Ustundag, Murad Atmaca   +4 more
doaj   +1 more source

Appraisal of Gene Expression‐Based Classifiers for Neuropsychiatric Disorders: A Meta‐Regression

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A substantial body of research examines the potential of gene‐expression‐based biomarkers for diagnosing and selecting treatments for neuropsychiatric disorders, yet no clear consensus has been reached regarding the influence of controllable factors such as study design and model selection on the performance of gene‐expression‐based ...
Ali Razavi, Brittany Arensman, Eric J. Barnett, Leo A. Lee, Stephen V. Faraone, Stephen J. Glatt, Jonathan L. Hess   +6 more
wiley   +1 more source