Results 251 to 260 of about 512,921 (340)

UGT1A1 Fragment Analysis: Genotyping the (TA)n Variable Repeat Polymorphism for Clinical Applications

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study developed a PCR‐based fragment analysis assay for UGT1A1 rs3064744 targeting TA5 (*36), TA6 (*1), TA7 (*28), and TA8 (*37). The assay was CLIA validated with data showing 100% concordance and a sensitivity of 0.5 ng/uL. The assay was then implemented in a patient cohort of n = 940 and the results compared with PharmacoScan.
Ryan N. Baugher   +6 more
wiley   +1 more source

Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria‐Induced Apoptosis Pathway

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Inhibition of XPO1 is a promising modality in the treatment of MDS, especially when combined with Venetoclax, which activates mitochondria‐mediated apoptosis and could be a potential target for MDS therapy. ABSTRACT Background Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies that pose a serious health threat.
Xiaohan Liu   +8 more
wiley   +1 more source

Exploring supported ionic liquids for IgY antibody purification

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Immunoglobulin Y (IgY), a scalable alternative to mammalian antibodies, typically found in hen's egg yolk, has gained attraction in diagnostic and therapeutic applications. However, its purification from egg yolk remains challenging due to the complex matrix and limitations of conventional techniques. Supported Ionic Liquids (SILs),
Amanda RP Silva   +4 more
wiley   +1 more source

Diagnostic modulation of subgingival proteomic biomarkers by age and smoking habits in periodontitis

open access: yesJournal of Periodontology, EarlyView.
Abstract Background Although age and smoking influence the periodontal proteome, their impact on subgingival biomarkers for diagnosing periodontitis remains unclear. This multicenter study assessed their influence on subgingival proteins for disease detection.
Triana Blanco‐Pintos   +8 more
wiley   +1 more source

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