Results 41 to 50 of about 141,132 (265)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
FOSS4G 2017 Full Conference Proceedings (papers and posters)
, 2017 This Conference Proceedings is a collection of outstanding papers and posters submitted to the Academic Program of the International Conference for Free and Open Source Software for Geospatial (FOSS4G), 14th to 19th August 2017 in Boston, U.S ...
Anderson, Andy +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Proceedings of the URECA@NTU 2007-2008
, 2008 Proceedings of the URECA@NTU 2007-08 is a compilation of selected URECA research papers, submitted by the URECA students of 2007-08, co-authored with their respective URECA professors.Published ...
Students of URECA Programme
core
Proceedings of the URECA@NTU 2015-2016
, 2016 Proceedings of the URECA@NTU 2015-16 is a compilation of selected URECA and FYP-URECA research papers, submitted by the URECA students of 2015-16, and under the supervision of their respective URECA professors.Published ...
Students of URECA Programme
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Proceedings of the URECA@NTU 2008-2009
, 2009 Proceedings of the URECA@NTU 2008-09 is a compilation of selected URECA and FYP-URECA research papers, submitted by the URECA students of 2008-09, coauthored with their respective URECA professors.Published ...
Students of URECA Programme
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Proceedings of the URECA@NTU 2009-2010
, 2010 Proceedings of the URECA@NTU 2009-10 is a compilation of selected URECA and FYP-URECA research papers, submitted by the URECA students of 2009-10, and under the supervision of their respective URECA professors.Published ...
Students of URECA Programme
core