Results 71 to 80 of about 147,672 (267)

Ipsilateral synchronous clear and papillary renal cell carcinoma: A case report and review of the literature

Urology Case Reports, 2018
Clear cell renal cell carcinoma and papillary renal cell carcinoma are the most common types of renal tumors. However, coexistence of both tumors in the same kidney is a rare condition.We report a 56-year old male who was found to have ipsilateral ...
Muna Alhusban, Sohaib Alhamss, Bayan Alzumaili, Ali Al-Daghmin   +3 more
doaj  

Morphological spectrum of Xp11. Translocation-Associated Renal Cell Carcinoma in a Developing Country

Pakistan Armed Forces Medical Journal, 2022
Objective: to determine unusual morphological features and a panel of immunohistochemical markers to diagnose Xp11 translocation carcinoma. Study Design: Retrospective longitudinal study. Place and Duration of Study: Shaukat Khanum Memorial Cancer
Iram Khan, Sana Ghulam Nabi, Sajid Mushtaq, Noreen Akhtar, Usman Hassan, Muddasir Hussain   +5 more
doaj   +1 more source

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

eLife, 2019
While genomic sequencing routinely identifies oncogenic alterations for the majority of cancers, many tumors harbor no discernable driver lesion. Here, we describe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell ...
Jianing Xu, Ed Reznik, Ho-Joon Lee, G. Gundem, P. Jonsson, Judy Sarungbam, Anna Bialik, F. Sánchez-Vega, Chad J Creighton, J. Hoekstra, Li Zhang, Peter Sajjakulnukit, Daniel M. Kremer, Zachary P. Tolstyka, J. Casuscelli, S. Stirdivant, Jie Tang, N. Schultz, Paul S Jeng, Yiyu Dong, Wenjing Su, Emily H Cheng, P. Russo, Jonathan A. Coleman, E. Papaemmanuil, Ying-bei Chen, V. Reuter, C. Sander, Scott R. Kennedy, James J Hsieh, C. Lyssiotis, S. Tickoo, A. Hakimi   +32 more
semanticscholar   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

Advanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
wiley   +1 more source

Artificial Intelligence‐Assisted Urine Cytology for Noninvasive Detection of Muscle‐Invasive Urothelial Carcinoma: A Multi‐Center Diagnostic Study with Prospective Validation

Advanced Science, EarlyView.
Accurate preoperative detection of muscle‐invasive urothelial carcinoma (MIUC) is crucial for clinical decision‐making. This study developed PUCAS‐M, an artificial intelligence (AI) model that analyzes urine cytology to assist in differentiating MIUC from non‐MIUC.
Runnan Shen, Fan Jiang, Xiaowei Huang, Guibin Hong, Yun Luo, Huan Wan, Ye Xie, Mengyi Zhu, Yun Wang, Bohao Liu, Ping Qin, Yahui Wang, Haoxuan Wang, Hongkun Yang, Zhen Lin, Rui Chen, Nengtai Ouyang, Jian Huang, Tianxin Lin, Shaoxu Wu   +19 more
wiley   +1 more source

A deep learning framework for automated classification of histopathological kidney whole-slide images

Journal of Pathology Informatics, 2022
Background: Renal cell carcinoma is the most common type of malignant kidney tumor and is responsible for 14,830 deaths per year in the United States. Among the four most common subtypes of renal cell carcinoma, clear cell renal cell carcinoma has the ...
Hisham A. Abdeltawab, Fahmi A. Khalifa, Mohammed A. Ghazal, Liang Cheng, Ayman S. El-Baz, Dibson D. Gondim   +5 more
doaj  

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Concomitant clear cell renal cell carcinoma with osseous metaplasia and papillary thyroid microcarcinoma: a case report with literature review

African Journal of Urology, 2023
Backgrounds Although calcifications have been observed in various renal masses, osseous metaplasia has very rarely been reported. Here, we present a case of concomitant clear cell renal cell carcinoma with osseous metaplasia and papillary thyroid ...
Saman S. Fakhralddin, Deedar K. Qader, Abdulwahid M. Salih, Ari M. Abdullah, Hiwa O. Baba, Soran H. Tahir, Aras J. Qaradakhy, Dilan S. Hiwa, Fahmi H. Kakamad   +8 more
doaj   +1 more source

Engineered Hydrogels Revolutionize Locoregional Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review systematically summarizes the latest research progress on injectable hydrogels in cancer immunotherapy, highlighting their unique advantages in precise immune activation, local drug‐controlled release, and immune microenvironment remodeling. These features provide innovative solutions to overcome the bottlenecks of systemic side effects and
Jiyong Wei, Chunliu Huang, Zenghua Zhou, Yanni Lan   +3 more
wiley   +1 more source