Results 81 to 90 of about 147,672 (267)

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Triple Threat: Three Primary Malignancies Simultaneously Involving Three Genitourinary Organs

Case Reports in Urology, 2023
Statistically, the chance of having concurrent renal cell carcinoma (RCC), urothelial carcinoma of the bladder (UC), and a neuroendocrine tumor (NET) of the renal parenchyma is less than one in a trillion. Herein, we describe an unusual case of a 67-year-
Katharina Mitchell, Reima El Naili, Lakshmikumar Pillai, Eric Mark Lopez, John Riordan, Wallis Marsh, Adam Luchey, Ali Hajiran   +7 more
doaj   +1 more source

SIRT7‐Mediated MVP Desuccinylation Facilitates Tongue Squamous Cell Carcinoma Progression by Activating JAK2/STAT3 Pathway

Cell Biology International, EarlyView.
ABSTRACT Major vault protein (MVP) plays a contributing role in multifarious cancers, and then its role in Tongue squamous cell carcinoma (TSCC) is uncomprehending. This study aimed to investigate the regulatory effect of MVP on malignant behavior of TSCC cells and its mechanism. We first pointed out the abnormal upregulation of MVP in tumor tissues by
Zhuo Zhang, Tingting Guo, Xiangyu Zhao
wiley   +1 more source

Distinct Genomic Copy Number Alterations Distinguish Mucinous Tubular and Spindle Cell Carcinoma of the Kidney From Papillary Renal Cell Carcinoma With Overlapping Histologic Features

American Journal of Surgical Pathology, 2018
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare type of renal cell carcinoma that frequently exhibits histologic and immunophenotypic features overlapping with type 1 papillary renal cell carcinoma (PRCC). To clarify molecular
Q. Ren, Lu Wang, H. Al-Ahmadie, S. Fine, A. Gopalan, S. Sirintrapun, S. Tickoo, V. Reuter, Ying-bei Chen   +8 more
semanticscholar   +1 more source

Robot‐Assisted Partial Nephrectomy for Multiple Synchronous Renal Tumors in Unilateral Kidney Using Hinotori Surgical System: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction Multiple synchronous renal tumors (MSRT) in unilateral kidney are clinically rare. Simultaneous resection for multiple tumors with RAPN is complicated and challenging. Herein, we report the successful resection of three synchronous renal tumors located in unilateral kidney with RAPN using the hinotori surgical robot system.
Kento Ozawa, Hiromitsu Watanabe, Kyohei Watanabe, Yuto Matsushita, Keita Tamura, Daisuke Motoyama, Atsushi Otsuka, Teruo Inamoto, Hideaki Miyake   +8 more
wiley   +1 more source

Papillary renal cell carcinoma: what is missing in research? A case report and a review of literature

SAGE Open Medical Case Reports, 2019
The incidence of renal cell carcinomas in adults ranges has been increasing over the past decades in both men and women. Once the incidence was 2.9%, now is reported to have increased to 3%–5% with male predominance according to the most recent reports ...
Ihab Eldessouki, Ola Gaber, Mahmoud A Shehata, Tariq Namad, Joseph Atallah, Harsha Masineni, Nagla Abdel Karim   +6 more
doaj   +1 more source

Dual role of KRT17: development of papillary renal cell tumor and progression of conventional renal cell carcinoma

Journal of Cancer, 2019
Expression of KRT17 has been described in multi-layered epithelia as well as in tumors derived from these cells. In cancers arising from KRT17 negative single layered epithelia neo-expression of KRT17 has been associated with tumor progression. To obtain
D. P. Sarlós, M. Yusenko, L. Péterfi, Árpád Szántó, G. Kovacs   +4 more
semanticscholar   +1 more source

TBCancer: A database for exploring characteristics and functions of tissue‐biased genes in cancer

iMetaOmics, EarlyView.
This study defined 10,921 tissue‐biased genes across 54 normal tissues and 41 cancer types. Tumor‐associated tissue‐biased genes exhibit downregulation, mutations, and epigenetic modifications, correlating with poor clinical outcomes. Their inactivation promotes tumorigenesis by enhancing stemness and immune evasion, highlighting their value as ...
Zhuobin Lin, Kunhua Hu, Hongyan Sun, Xiaoqiong Bao, Lin Tang, Wei Liu, Zhixiang Zuo, Zhihang Chen   +7 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Assessment of the Effects of Cigarette Smoke on the Renal Morphology of WISTAR Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT Smoking is a major public health concern worldwide. The toxic components of cigarettes, such as nicotine, can cause abuse, dependence, and tissue damage. This study aimed to evaluate the effects of exposure to cigarette smoke on the renal morphology of Wistar rats.
Cristiane Gomes Fernandes Freire, Luana Aparecida Cunha, Mateus Andrade Stecca, Isabele Masson de Brito, Rafaella Riccio da Silva, Thiago Donizeth da Silva, Margarida Pereira Santos, Márcia Cristina Bizinotto de Assunção, Geraldo José Medeiros Fernandes, Evelise Aline Soares   +9 more
wiley   +1 more source