Results 61 to 70 of about 14,159 (238)

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

Advanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
wiley   +1 more source

Characterizing the outcomes of metastatic papillary renal cell carcinoma [PDF]

Cancer Medicine, 2017
AbstractOutcomes of metastatic papillary renal cell carcinoma (pRCC) patients are poorly characterized in the era of targeted therapy. A total of 5474 patients with metastatic renal cell carcinoma (mRCC) in the International mRCC Database Consortium (IMDC) were retrospectively analyzed.
Toni K. Choueiri, Neeraj Agarwal, Georg A. Bjarnason, Felice Pasini, Lori Wood, John Connor Wells, John Connor Wells, Sandy Srinivas, Jae-Lyun Lee, Sun Young Rha, Ulka N. Vaishampayan, Robin Simpson, Guillermo de Velasco, Isaac Bowman, Anna Paola Fraccon, Daniel Y.C. Heng, Jennifer J. Knox, Douglas Scott Ernst, Frede Donskov, Sumanta K. Pal, Benoit Beuselinck   +20 more
openaire   +4 more sources

Artificial Intelligence‐Assisted Urine Cytology for Noninvasive Detection of Muscle‐Invasive Urothelial Carcinoma: A Multi‐Center Diagnostic Study with Prospective Validation

Advanced Science, EarlyView.
Accurate preoperative detection of muscle‐invasive urothelial carcinoma (MIUC) is crucial for clinical decision‐making. This study developed PUCAS‐M, an artificial intelligence (AI) model that analyzes urine cytology to assist in differentiating MIUC from non‐MIUC.
Runnan Shen, Fan Jiang, Xiaowei Huang, Guibin Hong, Yun Luo, Huan Wan, Ye Xie, Mengyi Zhu, Yun Wang, Bohao Liu, Ping Qin, Yahui Wang, Haoxuan Wang, Hongkun Yang, Zhen Lin, Rui Chen, Nengtai Ouyang, Jian Huang, Tianxin Lin, Shaoxu Wu   +19 more
wiley   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Engineered Hydrogels Revolutionize Locoregional Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review systematically summarizes the latest research progress on injectable hydrogels in cancer immunotherapy, highlighting their unique advantages in precise immune activation, local drug‐controlled release, and immune microenvironment remodeling. These features provide innovative solutions to overcome the bottlenecks of systemic side effects and
Jiyong Wei, Chunliu Huang, Zenghua Zhou, Yanni Lan   +3 more
wiley   +1 more source

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma [PDF]

New England Journal of Medicine, 2016
Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell carcinomas, is a heterogeneous disease that consists of various types of renal cancer, including tumors with indolent, multifocal presentation and solitary tumors with an aggressive, highly lethal phenotype.
Joseph Paulauskis, Gordon Saksena, Nilsa C. Ramirez, Jay Engel, Nandita Barnabas, Sara Sadeghi, Eve Shinbrot, Alan P. Hoyle, Rajiv Dhir, Jacqueline E. Schein, Satish K. Tickoo, Andrew Salner, Payal Sipahimalani, Alicia Hawes, James J. Hsieh, Laura S. Schmidt, Robert A. Holt, Paul M. Weinberger, Bhavani Krishnan, Peter W. Laird, Fengju Chen, Maria Merino, Janae V. Simons, David A. Wheeler, David Mallery, Mary Iacocca, Pavana Anur, Rebecca Carlsen, Andrew K. Godwin, Thai H. Ho, Saianand Balu, Leigh B. Thorne, Lori Boice, Mark D.M. Leiserson, Iakovina Alexopoulou, Adrian Ally, Ranabir Guin, Richard A. Moore, Rameen Beroukhim, Tara M. Lichtenberg, Kyle R. Covington, Suzanne S. Fei, Lisa Wise, Shiyun Ling, Michael Lobis, Paul T. Spellman, Julie Bergsten, Ye Wu, Michael M. Ittmann, Kevin Lau, Robert Penny, Matthew D. Wilkerson, Jeff Boyd, Jiashan Zhang, Stacey Gabriel, George Thomas, J. Todd Auman, Ying-Bei Chen, Jay Bowen, Roy Tarnuzzer, D. Neil Hayes, Kristen M. Leraas, Rashi Naresh, Amanda Clarke, Stuart R. Jefferys, W. Kimryn Rathmell, Tom Bodenheimer, Tracie Santos, Katayoon Kasaian, Laurence Albiges, Jun Li, Laura Dike, Jeremy Parfitt, Johanna Gardner, Min Wang, Scott Morris, Margi Sheth, Lora Lewis, Roni J. Bollag, Bradley A. Murray, John N. Weinstein, Junyuan Wu, Donghui Tan, Heidi J. Sofia, Donna Morton, Matthew Meyerson, Matthew G. Soloway, Yan Shi, Scott McMeekin, Ninad Dewal, Hsu Chao, Eric M. Thompson, Samira A. Brooks, Daniel Crain, Carolyn M. Hutter, Miruna Balasundaram, Angela Tam, Yaron S.N. Butterfield, Monique Albert, W. Marston Linehan, Jodi K. Maranchie, Scott L. Carter, Hui Shen, Shaowu Meng, Jean C. Zenklusen, Han Liang, Christie Kovar, Yiling Lu, Noreen Dhalla, Gordon B. Mills, Walker Hale, Ramaprasad Srinivasan, Reanne Bowlby, William Y. Kim, Cynthia Winemiller, Candace Shelton, Lisle E. Mose, Donna M. Muzny, John Eckman, Julie M. Gastier-Foster, Sheldon I. Bastacky, Myron Peto, Jia Liu, Jerome Myers, Donald P. Bottaro, A. Gordon Robertson, Abu Amar M. Al Mamun, Joel Slaton, Yao Fu, Kenna R. Mills Shaw, April DeVolk, Erik P. Castle, Brian Shuch, Moiz S. Bootwalla, Tina Wong, Somak Roy, John A. Demchok, Rosemary E. Zuna, Melissa L. Stanton, Corbin D. Jones, Stephen B. Baylin, Carl Simon Shelley, Cathy D. Vocke, Julien Baboud, David Haussler, Daniel J. Weisenberger, Benjamin J. Raphael, Andrew J. Mungall, Toni K. Choueiri, Sabina Signoretti, Jason Bedford, Andrew D. Cherniack, Erik Zmuda, Qiang Sun, Steven J.M. Jones, Zhining Wang, Rehan Akbani, Sudha Chudamani, Leigh Anne Zach, Mark E. Sherman, David Van Den Berg, Harsha Doddapaneni, W. Troy Shelton, Pheroze Tamboli, Joel Nelson, Yunhu Wan, Scott M. Haake, Nicholas J. Petrelli, Richard A. Gibbs, Liu Xi, Jennifer Drummond, John Bartlett, Jeremiah J. Andersen, Anil V. Parwani, Nina Thiessen, Christopher J. Ricketts, Lori Huelsenbeck-Dill, Ronald L. Hrebinko, Joel S. Parker, Tara Skelly, Divya Kalra, Michael L. Blute, Mei Huang, Melissa T. Avedon, Ed Reznik, Umadevi Veluvolu, Benjamin Davies, Liming Yang, Yussanne Ma, Bogdan Czerniak, Angela N. Brooks, Denise Brooks, Kelinda Tucker, Marco A. Marra, Christian J. Buhay, Mahmoud Dahdouli, Victor E. Reuter, Bruce L. Jacobs, Jie Li, Laxmi Lolla, Piotr A. Mieczkowski, Katherine A. Hoadley, Charles M. Perou, Caleb F. Davis, Jeffrey Roach   +204 more
openaire   +4 more sources

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Papillary renal cell carcinoma with malakoplakia: A unique case

Human Pathology Reports, 2022
The reported cases of malakoplakia concurrent with renal cell carcinoma (RCC) are exceedingly rare. Two prior cases of malakoplakia have been previously reported in patients with clear cell renal cell carcinoma.
Abigail A. Roth, Ashmi Patel, Haneen Salah, Luan D. Truong, Ziad M. El-Zaatari   +4 more
doaj  

SIRT7‐Mediated MVP Desuccinylation Facilitates Tongue Squamous Cell Carcinoma Progression by Activating JAK2/STAT3 Pathway

Cell Biology International, EarlyView.
ABSTRACT Major vault protein (MVP) plays a contributing role in multifarious cancers, and then its role in Tongue squamous cell carcinoma (TSCC) is uncomprehending. This study aimed to investigate the regulatory effect of MVP on malignant behavior of TSCC cells and its mechanism. We first pointed out the abnormal upregulation of MVP in tumor tissues by
Zhuo Zhang, Tingting Guo, Xiangyu Zhao
wiley   +1 more source