Results 51 to 60 of about 152,043 (303)

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Papillary thyroid carcinoma

, 2018
Although most thyroid nodules are a result of a benign disease process (>90%), the possibility of thyroid cancer is always a consideration. Ultrasonography can help for differential diagnosis of thyroid nodules. Fine needle aspiration biopsy is the traditional diagnostic test to determine malignancy in thyroid nodules.
Yasemin Giles Şenyürek, İsmail Cem Sormaz   +1 more
openaire   +3 more sources

Aggressive histopathological variants of papillary thyroid carcinoma, diagnostic challenge, and clinical significance—A case series

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2022
Papillary thyroid carcinoma is the most common form of thyroid cancer and is usually associated with a good outcome. However, there are some aggressive variants wherein the prognosis may not be as good as for a conventional papillary thyroid carcinoma ...
P K Pravanya, K R Anila, Shaji Thomas, A Sreekumar, K Jayasree   +4 more
doaj   +1 more source

MicroRNA Expression in the Progression and Aggressiveness of Papillary Thyroid Carcinoma

Anticancer Research, 2019
In the last two decades microRNAs have received great attention in research because of their ability to regulate gene expression. Many studies have shown that defects in different microRNA molecules are linked to many diseases; however, their ...
Agnieszka Zembska, Aleksandra JAWIARCZYK-PRZYBYŁOWSKA, Beata Wojtczak, M. Bolanowski   +3 more
semanticscholar   +1 more source

Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé, Lucía García‐DeLaFuente, Alejandro García‐Álvarez, Ginesa García‐Rostán, Jaume Capdevila, Jorge Hernando   +5 more
wiley   +1 more source

Metachronous Follicular Variant of Papillary Thyroid Microcarcinoma in a Case of Medullary Carcinoma Thyroid [PDF]

Journal of Krishna Institute of Medical Sciences University, 2016
Medullary carcinoma and papillary thyroid carcinoma arise from the different cells. Simultaneous occurrence of both types is rare. Medullary carcinomas are characterised by calcitonin positivity.
Neelam Sood, Binit Kumar Khandelia
doaj  

Huge posterior triangle lymphadenopathy as a rare sole presentation of papillary thyroid carcinoma

Pediatria i Medycyna Rodzinna, 2019
Papillary thyroid carcinoma is well-known for its low malignant potential with good prognostic outcome. It usually presents as a palpable thyroid mass but scarcely manifests as an isolated cervical lymphadenopathy. A 50-year-old man presented with a huge
Don Evana Ezrien, Nury Namerra Buhari, Firdaus Hayati, Nornazirah Azizan, Doreen LP Lee, Siti Zubaidah Sharif, Irfan Mohamad   +6 more
doaj   +1 more source

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

Head &Neck, EarlyView.
ABSTRACT Background Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a 20% recurrence rate. Bitter taste receptors (T2Rs) and their genes (TAS2Rs) may regulate survival in solid tumors. This study examined T2R expression and function in PTC cells.
Kimberly Wei, Brianna L. Hill, Joel C. Thompson, Zoey A. Miller, Arielle Mueller, Robert J. Lee, Ryan M. Carey   +6 more
wiley   +1 more source

Unusual Presentation of Cystic Papillary Thyroid Carcinoma

Case Reports in Endocrinology, 2012
Papillary thyroid carcinoma is the most common thyroid malignancy, accounting for 80% of all thyroid cancers. The most common presentation of thyroid cancer is an asymptomatic thyroid mass or a nodule.
Vijayraj S. Patil, Abhishek Vijayakumar, Neelamma Natikar   +2 more
doaj   +1 more source

Detection of PTEN Mutations in Fine Needle Aspiration Biopsies of Indeterminate Thyroid Nodules: Impact on Diagnosis and Prognosis

Head &Neck, EarlyView.
ABSTRACT Background Data connecting PTEN mutations with thyroid cancer risk for indeterminate nodules remain limited due to the rare nature of these mutations. The aim of this study was to determine the relationship between PTEN mutations identified in cytologically indeterminate nodules and final pathology and clinical outcomes.
Lauren E. Schlegel, Madelaine Brill‐Edwards, Zi‐Xuan Wang, Christopher McNair, Stacey Gargano, Elizabeth Cottrill   +5 more
wiley   +1 more source