Results 61 to 70 of about 150,574 (342)

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken   +3 more
wiley   +1 more source

Metastatic Papillary Thyroid Carcinoma with Multifocal Synchronous Transformation to Anaplastic Thyroid Carcinoma

open access: yesCase Reports in Pathology, 2016
Papillary thyroid carcinoma is a common malignancy to affect the thyroid and is typified by a nonaggressive nature and low rates of mortality. In contrast, anaplastic thyroid carcinoma is the most aggressive thyroid malignancy with a mortality rate of ...
Mark Benedict, Jose Costa
doaj   +1 more source

Aggressive histopathological variants of papillary thyroid carcinoma, diagnostic challenge, and clinical significance—A case series

open access: yesMedical Journal of Dr. D.Y. Patil Vidyapeeth, 2022
Papillary thyroid carcinoma is the most common form of thyroid cancer and is usually associated with a good outcome. However, there are some aggressive variants wherein the prognosis may not be as good as for a conventional papillary thyroid carcinoma ...
P K Pravanya   +4 more
doaj   +1 more source

A Robust Deep Learning Method with Uncertainty Estimation for the Pathological Classification of Renal Cell Carcinoma based on CT Images [PDF]

open access: yesarXiv, 2023
Objectives To develop and validate a deep learning-based diagnostic model incorporating uncertainty estimation so as to facilitate radiologists in the preoperative differentiation of the pathological subtypes of renal cell carcinoma (RCC) based on CT images.
arxiv  

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

open access: yesAdvanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu   +12 more
wiley   +1 more source

Thyroid hemangioma and concurrent papillary thyroid carcinoma

open access: yesOtolaryngology Case Reports, 2021
Background: Hemangiomas are benign vascular neoplasms resulting from abnormal vascular proliferation. Thyroid hemangiomas are rare occurrences with only 33 cases reported in the literature.
Robert T. Cristel   +6 more
doaj  

NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States

open access: yesCancer, 2016
An increase in thyroid cancers, predominantly papillary thyroid carcinoma (PTC), has been recently reported in children.
M. Prasad   +11 more
semanticscholar   +1 more source

AKT1E17K‐Interacting lncRNA SVIL‐AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation

open access: yesAdvanced Science, EarlyView.
Wang et al. discover a novel lncRNA regulator of mutant oncoprotein which prevents AKT1E17K dephosphorylation. SVIL‐AS1 overexpression correlates with poor prognosis of breast cancer patients. It interacts with AKT1E17K protein and impedes PP2A holoenzyme from dephosphorylating AKT1 by blocking the binding of the regulatory subunit PPP2R2A to AKT1 ...
Jingyi Wang   +8 more
wiley   +1 more source

High CX3CR1 expression predicts poor prognosis in paediatric acute myeloid leukaemia undergoing hyperleukocytosis

open access: yesInternational Journal of Laboratory Hematology, Volume 45, Issue 1, Page 53-63, February 2023., 2023
Abstract Introduction Paediatric AML patients with hyperleukocytosis have a poor prognosis and higher early mortality. Therefore, more studies are needed to explore relevant prognostic indicators and develop effective prevention strategies for this type of childhood AML. Methods All original data were obtained from the TARGET database.
Nan Mei   +6 more
wiley   +1 more source

Huge posterior triangle lymphadenopathy as a rare sole presentation of papillary thyroid carcinoma

open access: yesPediatria i Medycyna Rodzinna, 2019
Papillary thyroid carcinoma is well-known for its low malignant potential with good prognostic outcome. It usually presents as a palpable thyroid mass but scarcely manifests as an isolated cervical lymphadenopathy. A 50-year-old man presented with a huge
Don Evana Ezrien   +6 more
doaj   +1 more source

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