Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter +5 more
wiley +1 more source
Para-Aortic Lymph Node Metastasis Detected by Sentinel Lymph Node Biopsy in Cervical Cancer Initially Presumed to be Stage IA2: A Case Report. [PDF]
Ouchi H +5 more
europepmc +1 more source
Non‐Dilute Synthesis of Macrodiolides and Macrotetrolides Enabled by Confinement Catalysis
Confinement catalysis within a hexameric resorcin[4]arene capsule enables macrolactonization under non‐dilute conditions (up to 0.1 M), overcoming the limitations of high‐dilution protocols (0.1–10 mM). This strategy provides direct access to 18–32‐membered macrodiolides and 26–32‐membered macrotetrolides in one pot and unlocks previously inaccessible ...
Feng‐Yuan Wang +3 more
wiley +1 more source
Educational intervention for nursing professionals on palliative care: quasi-experimental study. [PDF]
Barros JA +5 more
europepmc +1 more source
1,7‐Digallatetracarborane: Between Nucleophilic closo‐Cluster and “Inverse Sandwich” Digallylene
A dianionic π‐ligand is used to make a Janus‐type twofold complex with low‐valent gallium Ga(+I). The resulting compound can be seen as and reveals the reactivity of both: a Wade‐type closo‐carborane cluster with nucleophilic Ga‐sites, as well as π‐ligand stabilized Ga(I) atoms in an inverse sandwich compound.
Julijan Sarcevic +4 more
wiley +1 more source
[Governance, organization, and task distribution in family planning in Latin America and the CaribbeanGovernança, organização e distribuição de tarefas no planejamento familiar na América Latina e no Caribe]. [PDF]
Gómez Ponce de León R +5 more
europepmc +1 more source
Rapid Fragment Screening by 19F Steady‐State Free Precession NMR
19F$^{19}{\rm F}$ SSFP NMR is a broadband and very sensitive experiment for detecting protein–ligand interactions. The method enables rapid fragment screening at low micromolar protein concentrations, even for challenging drug targets such as intrinsically disordered proteins.
Laura Ruduša +8 more
wiley +1 more source
Will non-invasive methods replace bone biopsy in patients with chronic kidney disease? [PDF]
Araujo DSG, Lobo Filho CO, Barbosa FR.
europepmc +1 more source

