Results 51 to 60 of about 6,262,155 (317)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A New Genus of Miniaturized and Pug-Nosed Gecko from South America (Sphaerodactylidae: Gekkota) [PDF]

, 2011
Sphaerodactyl geckos comprise five genera distributed across Central and South America and the Caribbean. We estimated phylogenetic relationships among sphaerodactyl genera using both separate and combined analyses of seven nuclear genes.
Bauer, Aaron M., Colli, Guarino R., Daza, Juan D., Gamble, Tony, Vitt, Laurie J.   +4 more
core   +2 more sources

Para-probiotics for Preterm Neonates—The Next Frontier

Nutrients, 2018
Current evidence supports the use of probiotics in preterm neonates for prevention of necrotizing enterocolitis, mortality and late onset sepsis.
G. Deshpande, G. Athalye-Jape, S. Patole
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Solos e avaliação da aptidão agrícola das terras do município de Inhangapi, Estado do Pará. [PDF]

, 2001
bitstream/item/63718/1/Oriental-Doc125.PDFAnexo 2 mapas: Mapa de aptidão agrícola das terras do Município de Inhangapi - Pará; Mapa de solos do Município de Inhangapi ...
CARVALHO, E. J. M., PEREIRA, I. C. B., RODRIGUES, T. E., ROLIM, P. A. M., SANTOS, P. L. dos, SILVA, E. S., SILVA, J. M. L. da, VALENTE, M. A.   +7 more
core  

Serologically defined variations in malaria endemicity in Pará state, Brazil [PDF]

, 2014
BACKGROUND: Measurement of malaria endemicity is typically based on vector or parasite measures. A complementary approach is the detection of parasite specific IgG antibodies. We determined the antibody levels and seroconversion rates to both P.
AC Marques, AJ Vyse, BF Arnold, CA Guerra, CA Guerra, CG Morais, CG Morais, Chris J. Drakeley, CJ Drakeley, D Sawyer, EC De Oliveira, Eleanor Riley, Eliane S. Silva, F Lu, FP Alves, GH Stresman, I Mueller, IG Kagan, IS Soares, IS Soares, IS Soares, J Cook, J Cook, J Cook, J Oliveira-Ferreira, J Sattabongkot, JC Stevenson, João F. Guerreiro, JR Coura, L Stewart, LH Carvalho, LMA Camargo, M Silva-Nunes, M Silva-Nunes, Marinete M. Póvoa, Maristela G. Cunha, MB Barbedo, ME De Carvalho, MG Cunha, Nuno Sepúlveda, OJ Akpogheneta, P Brasil, P Corran, Patrick H. Corran, PH Corran, RN Price, S Ladeia-Andrade, Sheyla P. T. Costa, SM Griffing, T Bousema, T Wickramarachchi, Tiago C. Saboia, Érika Martins Braga   +52 more
core   +4 more sources

Systematic review and meta-analysis of bovine cysticercosis in Brazil : current knowledge and way forward [PDF]

, 2020
Background Taenia saginata taeniosis/cysticercosis has been well studied in several countries. Brazil is one of the most important beef exporting countries and has one of the highest cattle population size in the world.
Gabriël, Sarah, Rossi, Gabriel Augusto Marques, Van Damme, Inge   +2 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

O TRABALHO DOCENTE: ELEMENTOS PARA UMA TEORIA DA DOCÊNCIA COMO PROFISSÃO DE INTERAÇÕES HUMANAS

, 2016
O livro O trabalho docente: Elementos para uma teoria da docencia como profissao de interacoes humanas , busca verificar o cerne do processo de escolarizacao analisando o trabalho dos individuos que efetivam essa atividade: os professores, os alunos e os
Camila Matos
semanticscholar   +1 more source

Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives

Nature Communications, 2018
Transition-metal-catalyzed direct site-selective functionalization of arene C–H bonds has emerged as an innovative approach for building the core structure of pharmaceutical agents and other versatile complex compounds.
Chunchen Yuan, Lei Zhu, Changpeng Chen, Xiaolan Chen, Y. Yang, Y. Lan, Yingsheng Zhao   +6 more
semanticscholar   +1 more source