Results 61 to 70 of about 34,570 (219)

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

Balkan Medical Journal, 2016
Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly.
İrfan Cicin, Tahsin Özatlı, Esma Türkmen, Türkan Özturk, Melike Özçelik, Devrim Çabuk, Ayşe Gökdurnalı, Özlem Balvan, Yaşar Yıldız, Metin Şeker, Nuriye Özdemir, Burcu Yapar, Özgür Tanrıverdi, Yusuf Günaydin, Serkan Menekşe, Berna Öksüzoğlu, Asude Aksoy, Bülent Erdoğan, M. Bekir Hacıoglu, Erkan Arpaci, Alper Sevinç, Mehmet Atilla Uysal, Sinem İliaz   +22 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Integração de modelos de localização a sistemas de informações geográficas Integration of location models to geographical information systems

Gestão & Produção, 2001
O problema de p-medianas consiste em decidir onde localizar p centros em uma rede composta por vértices e arestas, de forma a minimizar a soma de todas as distâncias de cada vértice ao centro mais próximo.
Luiz Antonio Nogueira Lorena, Edson Luiz França Senne, João Argemiro de Carvalho Paiva, Marcos Antonio Pereira   +3 more
doaj   +1 more source

Inpatient Exposure, Confidence, and Knowledge in Pediatric Hematology/Oncology: Evaluating General Pediatric Residents During 2025 ACGME Curriculum Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley   +1 more source

Estudo do poder e tamanho do teste de Levene multivariado via simulação Monte Carlo e bootstrap = Evaluating the power and the size of multivariate Levene’s test using Monte Carlo simulation and bootstrap

Acta Scientiarum: Technology, 2006
Este trabalho tem por objetivo avaliar a taxa de erro tipo I e o poder do teste de Levene multivariado definido em função de diferentes parâmetros de posição para comparar k-matrizes de covariâncias.
Marcelo Angelo Cirillo, Daniel Furtado Ferreira, Thelma Sáfadi   +2 more
doaj  

Ultrasound-guided spinal anesthesia in ankylosing spondylitis patients: Enhancing safety and efficacy

Journal of Current Research in Scientific Medicine
Ankylosing spondylitis is an immunomediated seronegative spondyloarthropathy involving the axial skeleton, sacroiliac joints, and peripheral joints. Our aim is to explore the feasibility of ultrasound-assisted spinal anesthesia procedure in ankylosing ...
S. Nazreen Begam, Eashwar Neelakandan, Jananimadi Seetharaman, Ramyavel Thangavelu   +3 more
doaj   +1 more source

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source

Enxertos valvares aórticos homólogos: estudo experimental em cães

Brazilian Journal of Cardiovascular Surgery, 1998
Vinte cães foram divididos em dois grupos de dez, sendo um o grupo doador (Grupo 1) e o outro, o receptor (Grupo 2). Todos os animais do grupo 1 foram submetidos a uma toracotomia mediana e sacrificados, para a retirada do coração e da valva aórtica; os ...
Rui Manoel Sequeira de ALMEIDA, Danton R. da Rocha LOURES, Hélcio GIFFHORN, Katia PIFFER, Ana Cláudia Araújo dos SANTOS, Maureen Aparecida de OLIVEIRA, Edison José RIBEIRO, Maria João Amorim FERREIRA   +7 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source