Results 121 to 130 of about 113,963 (269)

O paradoxo na Teoria da Argumentação na Língua: uma questão linguístico-argumentativa = The paradox in Language Argumentation Theory: a linguisticargumentative issue

open access: yesActa Scientiarum: Language and Culture, 2009
Na Teoria da Argumentação na Língua (TAL), o conceito de paradoxo estáligado à hipótese de que ele pode ser definido em termos puramente linguísticos. Nessa definição, entende-se que há uma argumentação estruturalmente relacionada a algumas expressões ...
Rosi Ana Grégis
doaj  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng   +14 more
wiley   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

open access: yesAdvanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee   +9 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

open access: yesAdvanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan   +13 more
wiley   +1 more source

Nanopore‐Based Protein Deceleration and Sensing Using Graphene/Si3N4 Dual Membrane Cavity

open access: yesAdvanced Science, EarlyView.
A graphene/Si3N4 dual membrane cavity system achieves multi‐stage protein deceleration through spatial geometry. Multi‐level current traces provide high‐resolution spatial localization and early warning signals. ABSTRACT Sequencing of protein with nanopores has emerged as a powerful tool offering rapid readout, high accuracy, low cost, and portability.
Yubin Cao, Junzhou He, Wei Si
wiley   +1 more source

The Obesity Paradox in Major Adverse Cardiovascular Events After PCI for Acute Coronary Syndrome: A Narrative Review. [PDF]

open access: yesJ Cardiovasc Dev Dis
Simioni L   +11 more
europepmc   +1 more source

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