Results 161 to 170 of about 1,405,451 (393)
Advanced Science, EarlyView.Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen +16 more
wiley +1 more source
I present a paradox concerning a person who desires to fail to achieve the goal that matters most to them. I recently encountered a similar paradox, but radical solipsism is a solution to it.
Edward, Terence Rajivan
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Advanced Science, EarlyView.Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li +12 more
wiley +1 more source
Advanced Science, EarlyView.Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann +3 more
wiley +1 more source
Applying the immobility theory to thoroughly solve the three Zeno’s paradoxes [PDF]
- Applying the law of conservation of time to solve the Achilles and the tortoise paradox. - Applying the smallest unit of time T_min in the universe to solve the Dichotomy paradox.
Khac Son, Ninh
core
Primary hypothyroidism with paradoxically elevated plasma thyroxine due to thyroxine-binding antibody [PDF]
, 1986 R V Hague, Sandra Higgins, Walter J. May
openalex +1 more source
Advanced Science, EarlyView.This study reveals the mechanism by which jasmonic acid (JA) regulates lycopene synthesis under light and dark conditions. In light, JA activates SlMYC2, which suppresses SlPIF1a and promotes SlPSY1 expression. In darkness, JA induces the acetyltransferase SlNATA1, which acetylates the dark‐accumulated SlPIF1a, thereby repressing SlPSY1 expression ...
Jiayi Xu +10 more
wiley +1 more source
The Lck Paradox: Because of Inconsistent Experimental Evidence, the Role of the Protein Tyrosine Kinase p56lck in Early Thymic Development Remains Poorly Defined [PDF]
, 1997 Klaus Eichmann
openalex +1 more source
The productivity paradox of information technology
CACM, 1993 Erik Brynjolfsson
semanticscholar +1 more source