Results 191 to 200 of about 956,237 (293)

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Correction: The parity paradox: does number of children (parity) influence breast cancer mortality across the life course? [PDF]

BMC Cancer
Pinchas-Mizrachi R, Bouhnik D.
europepmc   +1 more source

Compartmentalized Homeostasis Drives High Bamboo Forest Productivity under Nutrient Imbalance

Advanced Science, EarlyView.
This study reveals how Moso bamboo achieves high productivity despite nutrient‐poor soils. It employs a unique strategy, maintaining strict nutrient balance in its leaves while using woody tissues as flexible storage reservoirs. This compartmentalized mechanism buffers the plant from soil phosphorus limitation and microbial competition, resolving the ...
Zhikang Wang, Quan Li, Man Shi, Marcio F.A. Leite, Xinli Chen, Eiko E. Kuramae, Viviane Cordovez, Tingting Cao, Chenglei Zhu, Libin Zhou, Wenjuan Yu, Zhiyao Tang, Changhui Peng, Xinzhang Song   +13 more
wiley   +1 more source

The obesity paradox revisited - influence on the results of percutaneous coronary interventions. [PDF]

AsiaIntervention
Movahed MR, Nathan A, Hashemzadeh M.
europepmc   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin‐induced Intestinal Injury by Production of Carboxylesterase EstB

Advanced Science, EarlyView.
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao, Qing Li, Xiaowu Bai, Ertao Zhai, Weigang Dai, Yan Qian, Tianhao Zhang, Zhixin Huang, Ziyu Huang, Fangang Meng, Jianhui Chen, Tao Zuo, Shirong Cai, Risheng Zhao   +13 more
wiley   +1 more source

Reconciling Coronary Artery Calcification in the Lipid-Lowering Era. [PDF]

JACC Adv
Khanna S, Nerlekar N, Bhat A.
europepmc   +1 more source

In Situ Construction of Cu1+/Cu0 and Cu2+/Cu0 Pairs of Cu‐Based Catalysts for Electrocatalytic Nitrate Reduction

Advanced Science, EarlyView.
CuO and CuPO (Cu2P2O7 and Cu3(PO4)2) as precursors are in suit construction two distinct copper‐based active sites during the NO3RR reaction: Cu1+/Cu0 (derived from CuO) and Cu2+/Cu0 (derived from CuPO). Cu1+/Cu0 is the key to achieving high activity and high selectivity.
Shanna An, Jiali Ren, Yanjun Xue, Jian Tian   +3 more
wiley   +1 more source