Results 41 to 50 of about 8,547 (244)

Molecular Creep Induced Fatigue Rupture of Fibrin Clots

Advanced Science, EarlyView.
Fibrin networks in thrombi paradoxically exhibit low fatigue resistance despite high fracture energy, as cyclic loading triggers irreversible α‐to‐β transitions in fibrin molecules, causing molecular creep, crack propagation. Multiscale experiments, modeling reveal how nanoscale conformational damage accumulates, linking molecular disorder to ...
Dani Liu, Zichang Jia, Binchao Liu, Jizhe Hou, Rui Bao, Mingkun Wang   +5 more
wiley   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, EarlyView.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Almost a Double Whammy! Acute Pulmonary Embolism and an Impending Paradoxical Embolism

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging
Pulmonary embolism (PE) is a relatively common cardiovascular disorder with high early mortality rates, despite advances in diagnosis and treatment. The risk of mortality is quite high in case the diagnosis is missed.
Raj Kumar, Rahul Mehrotra
doaj   +1 more source

Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Annals of Neurology, EarlyView.
Objective The efficacy and safety of intra‐arterial thrombolysis (IAT) as an adjunct to endovascular thrombectomy (EVT) in large vessel occlusion strokes (LVOS) remain uncertain, with recent randomized controlled trials (RCTs) yielding conflicting results.
Mohamed F. Doheim, Mahmoud H. Mohammaden, Ammar Jumah, Qingwu Yang, Wenjie Zi, Yangmei Chen, Yamei Tang, Yajie Liu, Xiaochuan Huo, Liping Liu, Bernard Yan, Zhongrong Miao, Wei Hu, Chunrong Tao, Xinfeng Liu, Liqun Jiao, Xuesong Bai, Wenhuo Chen, Diogo C. Haussen, Thanh Nguyen, Raul G. Nogueira   +20 more
wiley   +1 more source

Cryptogenic stroke. Part 2: paradoxical embolism

Медицинский совет, 2021
Cryptogenic stroke (CS) is defined as a subtype of stroke associated with a heterogeneous group of pathogenetic mechanisms that remained undetermined in the course of advanced diagnostic research.
A. A. Kulesh, D. A. Demin, A. V. Belopasova, S. A. Mekhryakov, O. I. Vinogradov, L. I. Syromyatnikova, A. A. Ziankou   +6 more
doaj   +1 more source

Multidisciplinary Management for Concomitant High-Risk Pulmonary Embolism and Large-Vessel Occlusion Stroke From Paradoxical Embolism

Annals of Internal Medicine: Clinical Cases
Concurrent pulmonary embolism (PE) and acute ischemic stroke are uncommon but associated with high morbidity. Paradoxical embolism occurs when thrombi cross right-to-left cardiac/pulmonary shunts such as a patent foramen ovale.
Phuong-Uyen Vo, Mark Rea, Justin Dunn, Aashish Anand, Madihah Hepburn   +4 more
doaj   +1 more source

Pulmonary embolism and patent foramen ovale thrombosis: the key role of TEE

Cardiovascular Ultrasound, 2007
This is a case report of a 35 young man with Klinefelter Syndrome presented breathlessness, palpitations and chest pain. It shows a rare case of a thrombus located through the PFO, in patient with pulmonary and paradoxical embolism, which takes back to ...
Reverberi Claudio, De Iaco Giuseppe, Serra Walter, Gherli Tiziano   +3 more
doaj   +1 more source

Patent Foramen Ovale and Stroke–Current Status [PDF]

Journal of Stroke, 2015
Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis ...
Oh Young Bang, Mi Ji Lee, Sookyung Ryoo, Suk Jae Kim, Ji Won Kim   +4 more
doaj   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

Epidemiology, pathophysiology, diagnosis and management of atrial functional mitral regurgitation: An expert opinion paper

ESC Heart Failure, EarlyView.
The graphical abstract summarizes the key features of AFMR in terms of epidemiology, pathophysiology, diagnosis, medical therapy and rhythm control, surgical and transcatheter interventions, and future directions. Created in BioRender (https://BioRender.com/3zj03ko).
Matteo Pagnesi, Mauro Riccardi, Francesco Maisano, Julia Grapsa, Vassilis Barberis, Magdy Abdelhamid, Elena‐Laura Antohi, Henrike Arfsten, Nicole Karam, Denisa Muraru, Karl‐Philipp Rommel, Anna Sannino, Wilfried Mullens, Marianna Adamo, Marco Metra   +14 more
wiley   +1 more source