Results 221 to 230 of about 109,391 (304)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

In vivo mechanical loading rapidly activates beta-catenin signaling in osteocytes through a prostaglandin mediated mechanism [PDF]

Aarden, Ajubi, Ajubi, Almeida, Armstrong, B. Javaheri, Bonewald, Bonewald, Boyden, Case, Case, Castellone, Chennimalai Kumar, Cherian, D.L. Ellies, Dallas, DasGupta, Donaldson, G. Thiagarajan, Galea, Genetos, Genetos, Gong, Harris, Javaheri, Jing, Johnson, Johnson, Jorgensen, Kalajzic, Kamel, Kato, Kitase, Klein-Nulend, Klein-Nulend, Klein-Nulend, Klein-Nulend, Komori, Kunnel, Lau, Li, Little, Loiselle, Lu, M.A. Kamel, M.L. Johnson, Mantila Roosa, Marotti, Moustafa, N. Lara-Castillo, N.A. Kim-Weroha, Nicolella, Noursadeghi, Patel, R.E. Krumlauf, Rath Bonivtch, Reyes, Robinson, Robling, Rubin, Sample, Santos, Sawakami, Saxon, Schaffler, Skerry, Sunters, Thiagarajan, Tu, Webster, Willie, Yang, You   +72 more
core   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Rice Straw Tissue Preparation for Reproducible Electron Microscopy Imaging and Analysis. [PDF]

Curr Protoc
Mohamadiaza M, Farrokhi N, Ingvarsson PK, Ahmadikhah A, Jahanfar M.   +4 more
europepmc   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Plant anatomy: The next episode-high throughput sectioning and image processing with AnatomyArray. [PDF]

Plant Cell
Kirschner GK.
europepmc   +1 more source

PROLONGED RAT CARDIAC PRESERVATION WITH UW LACTOBIONATE SOLUTION [PDF]

, 1989
CHAPMAN, F, KORMOS, R, MAKOWKA, L, MURASE, N, QIAN, SG, SNYDER, J, STARZL, TE, SUN, H, ZERBE, TR   +8 more
core  

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source