Results 51 to 60 of about 37,808 (300)

Solid state power mapping instrument Patent [PDF]

, 1964
Solid state device for mapping flux and power in nuclear reactor ...
Schwab, W. B., Steinberg, R.
core   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

A theoretical study on throttle ranges of O/F controllable hybrid rocket propulsion systems

Journal of Fluid Science and Technology, 2018
The characteristics of several O/F control methods for hybrid rocket propulsion have been discussed and theoretically analyzed from the physical properties of propellants and fuel regression behavior.
Kohei OZAWA, Toru SHIMADA
doaj   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Experimental Investigation of a H₂O₂ Hybrid Rocket with Different Swirl Injections and Fuels

Applied Sciences
Hybrid rockets have very interesting characteristics like simplicity, reliability, safety, thrust modulation, environmental friendliness and lower costs, which make them very attractive for several applications like sounding rockets, small launch ...
Manuel Stella, Lucia Zeni, Luca Nichelini, Nicolas Bellomo, Daniele Pavarin, Mario Tindaro Migliorino, Marco Fabiani, Daniele Bianchi, Francesco Nasuti, Christian Paravan, Luciano Galfetti, Attilio Cretella, Rocco Carmine Pellegrini, Enrico Cavallini, Francesco Barato   +14 more
doaj   +1 more source

EXPOSURE CHARACTERIZATION AND POTENTIAL HEALTH IMPACTS OF DOMESTIC FUEL USE IN HOMES IN KHAYELITSHA, WESTERN CAPE

Clean Air Journal, 1996
The pattern of fuel use in Lower socio-economic class homes in the Western Cape differs from that in Gauteng province, in that the use of paraffn and gas predominates. The degree of exposure to gaseous and particulate pollutants as a result of the use of
R. Truter, S. Mbuli, R. Bailie, I. Danford, A.P.S. Terblanche, R. Ehrlich   +5 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Association between cooking fuels and mild cognitive impairment among older adults from six low- and middle-income countries

Scientific Reports, 2022
There is a small body of evidence suggesting that unclean cooking fuel use may be associated with cognitive decline. However, to date, no study has investigated the association between unclean cooking fuel and mild cognitive impairment (MCI).
Lee Smith, Damiano Pizzol, Guillermo F. López Sánchez, Karel Kostev, Hans Oh, Louis Jacob, Nicola Veronese, Benjamin R. Underwood, Laurie Butler, Yvonne Barnett, Mark A. Tully, Ai Koyanagi   +11 more
doaj   +1 more source