Results 81 to 90 of about 3,658,490 (342)

Can intraoperative ultrasound replace the frozen section in the assessment of ex vivo sentinel lymph node biopsy in early breast cancer in countries with limited resources?

The Egyptian Journal of Radiology and Nuclear Medicine, 2021
Background Accurate staging and proper management of axillary lymph nodes (ALNs) in breast cancer patients are important for treatment. Surgical management of the axilla has evolved greatly in the last 20 years.
Rasha Wessam Abdel Rahman, Emad Salaheldin Khallaf, Lamia Adel Salaheldin, Mohamed Nasr Hafez, Mohannad Aly Fayed, Somia Abdulatif Mahmoud Soliman   +5 more
doaj   +1 more source

P53 mutations in human adrenocortical neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Allolio, B., Chrousos, G. P., Karl, M., Linehan, M., Mastorakis, G., Reincke, Martin, Travis, W.   +6 more
core  

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. [PDF]

, 2017
A major challenge in stem cell differentiation is the availability of bioassays to prove cell types generated in vitro are equivalent to cells in vivo. In the mouse, differentiation of primordial germ cell-like cells (PGCLCs) from pluripotent cells was ...
Chen, Di, Clark, Amander T, Hennebold, Jon D, Lam, Truong N, Meistrich, Marvin L, Mitchell, Jennifer M, Orwig, Kyle E, Peters, Karen A, Rojas, Ernesto J, Shetty, Gunapala, Sosa, Enrique, Sukhwani, Meena, Tailor, Ramesh C, Wu, Zhuang   +13 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Localization of complement factor H gene expression and protein distribution in the mouse outer retina. [PDF]

, 2015
To determine the localization of complement factor H (Cfh) mRNA and its protein in the mouse outer retina.Quantitative real-time PCR (qPCR) was used to determine the expression of Cfh and Cfh-related (Cfhr) transcripts in the RPE/choroid.
Estep, Jason, Gong, Qizhi, Hjelmeland, Leonard M, Nguyen, Anthony T, Oltjen, Sharon L, Radu, Roxana A, Smit-McBride, Zeljka   +6 more
core   +1 more source

Microscopy with ultraviolet surface excitation for rapid slide-free histology. [PDF]

, 2017
Histologic examination of tissues is central to the diagnosis and management of neoplasms and many other diseases, and is a foundational technique for preclinical and basic research.
Bishop, John, Borowsky, Alexander D, Demos, Stavros G, Fereidouni, Farzad, Harmany, Zachary T, Kintner, John A, Lechpammer, Mirna, Levenson, Richard, McPherson, John D, Tian, Miao, Todd, Austin   +10 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Leydig cells express neural cell adhesion molecules in vivo and in vitro [PDF]

, 1992
The neural cell adhesion molecule (NCAM) polypeptides are expressed by numerous tissues during embryonic development, where they are involved in cell-cell interactions.
Barthels, D., Bitter-Suermann, D., Christoph, A., Gratzl, Manfred, Lahr, G., Mayerhofer, Artur, Seidl, K., Wille, W.   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A single simple procedure for dewaxing, hydration and heat-induced epitope retrieval (HIER) for immunohistochemistry in formalin fixed paraffin-embedded tissue

European Journal of Histochemistry, 2015
Heat-induced epitope retrieval (HIER) is widely used for immunohistochemistry on formalin fixed paraffin-embedded tissue and includes temperatures well above the melting point of paraffin.
I.M.S. Paulsen, H. Dimke, S. Frische
doaj   +1 more source