Results 101 to 110 of about 3,741,686 (304)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Third-Order Effective Properties for Random-Packing Systems Using Statistical Micromechanics Based on a GPU Parallel Algorithm in Fast Computing n-Point Correlation Functions. [PDF]

Materials (Basel), 2022
Sun S, Chen H, Lin J.
europepmc   +1 more source

Delimited Massively Parallel Algorithm based on Rules Elimination for Application of Active Rules in Transition P Systems [PDF]

, 2007
In the field of Transition P systems implementation, it has been determined that it is very important to determine in advance how long takes evolution rules application in membranes.
Gil Rubio, Fco. Javier, Fernández Muñoz, Luis, Tejedor Cerbel, Jorge A., Arroyo Montoro, Fernando   +3 more
core   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Fabio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

(1) time Parallel Agorithm for Finding 2D Convex Hull on a Reconfigurable Mesh Computer Architecture [PDF]

, 2021
In this paper we propose a parallel algorithm in image processing in (1) time, intended for a parallel machine '' Reconfigurable Mesh Computer (RMC), of size n x n Elementary Processors (PE). The algorithm consists in determining the convex envelope of a
Omar Bouattane, Mohammed Khaldoun, Jelloul Elmesbahi, Ahmed Errami   +3 more
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

A Novel Method for Aircraft Structural Dynamic Strain Trend Signal Processing via Optimized Parallel Computing

Applied Sciences
In this study, we investigate the underlying causes of drift in the time history curves of measured parameters obtained through strain electrical measurements and assess their impacts on load measurements.
Yongwei Tian, Fang Zhang, Jinhui Jiang, Zhe Fan   +3 more
doaj   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

An Algorithm for Solving the Problem of Phase Unwrapping in Remote Sensing Radars and Its Implementation on Multicore Processors

Mathematics
The problem of the interferometric phase unwrapping in radar remote sensing of Earth systems is considered. Such interferograms are widely used in the problems of creating and updating maps of the relief of the Earth’s surface in geodesy, cartography ...
Petr S. Martyshko, Elena N. Akimova, Andrey V. Sosnovsky, Victor G. Kobernichenko   +3 more
doaj   +1 more source