Results 191 to 200 of about 329,729 (302)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Parallel evolution of fluconazole resistance and tolerance in Candida glabrata. [PDF]

Front Cell Infect Microbiol
Zheng L, Xu Y, Wang C, Dong Y, Guo L.
europepmc   +1 more source

Interaction between mutation type and gene pleiotropy drives parallel evolution in the laboratory. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Ruelens P, Wynands T, de Visser JAGM.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Gene losses, parallel evolution and heightened expression confer adaptations to dedicated cleaning behaviour. [PDF]

BMC Biol, 2023
Kang J, Ramirez-Calero S, Paula JR, Chen Y, Schunter C.   +4 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Functional Characterization of Luciferase in a Brittle Star Indicates Parallel Evolution Influenced by Genomic Availability of Haloalkane Dehalogenase. [PDF]

Mol Biol Evol
Lau ES, Majerova M, Hensley NM, Mukherjee A, Vasina M, Pluskal D, Damborsky J, Prokop Z, Delroisse J, Bayaert WS, Parey E, Oliveri P, Marlétaz F, Marek M, Oakley TH.   +14 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

The Predicted Structure of <i>S. cerevisiae</i> Ssp1 Reveals Parallel Evolution in the Pil1 BAR Domain Family Proteins of <i>Ascomycetes</i>. [PDF]

J Fungi (Basel)
Suda Y, Neiman AM.
europepmc   +1 more source

Parallel evolution and control method for predicting the effectiveness of non-pharmaceutical interventions in pandemics. [PDF]

J Public Health (Berl), 2023
Huang HN, Xie T, Chen WF, Wei YY.
europepmc   +1 more source