Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
The Mediating Role of Self-Control and Shame Between Sensitivity to Punishment and Intimacy. [PDF]
Brain BehavMirzazade Z, Dehshiri G, Zahraie S.
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Factor analysis validates the internal structure of the Cerebellar Neuropsychiatric Rating Scale Version 2 and the five domains of cerebellar neuropsychiatry. [PDF]
Front NeurolBurt AL, Schmahmann JD.
europepmc +1 more source
Hybrid PSO-GWO optimization for converter-free grid integration of parallel induction generators with experimental validation in micro-hydro power plants. [PDF]
Sci RepRajak MK, Meitei IC, Pudur R.
europepmc +1 more source
Fatigue Failure Mechanism and Crack Growth Behavior of Ti-6Al-4V ELI Titanium Alloy Welded Joints. [PDF]
Materials (Basel)Liu J, Li Y, Rui SS, Chen W, Sun C.
europepmc +1 more source
A Unified Neural Time Course for Words, Phrases, and Sentences: MEG Evidence from Parallel Presentation. [PDF]
Neurobiol Lang (Camb)Flower N, Pylkkänen L.
europepmc +1 more source
The Aggregated Latent Profile Index: Measuring Person Profile Differentiation Within a Bootstrap-Validated Latent Profile Space. [PDF]
Educ Psychol MeasKim SK.
europepmc +1 more source