RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential. [PDF]
Front Cell Dev BiolShi Q, Li Y, Guan C.
europepmc +1 more source
Advanced Science, EarlyView.A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee +9 more
wiley +1 more source
More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health. [PDF]
Philos Trans R Soc Lond B Biol SciLabbadia J.
europepmc +1 more source
Advanced Science, EarlyView.This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang +6 more
wiley +1 more source
Mitochondrial Quality Control Imbalance in the Heterogeneity of Parkinson's Disease: From Selective Vulnerability to Stratified Transformation. [PDF]
Int J Mol SciChen Y, Wang C.
europepmc +1 more source
Advanced Science, EarlyView.A nuclear‐pore‐inspired nested dual‐loop architecture redistributes electromagnetic energy through coupled transport, confinement, and dissipation pathways. Integrated with Co/Fe3O4 dual‐magnetic composites and topology optimization, the 11‐mm‐thick absorber delivers continuous 2–40 GHz attenuation, raises finite‐band structural utilization to 82%, and
Shaokang Liu +6 more
wiley +1 more source
Real-Case Validation of a Weather-Driven Two-Stage Geese V-Formation Algorithm for Distributed Generation Planning and Voltage-Security Assessment in Multi-Feeder Distribution Networks. [PDF]
Sensors (Basel)Saeed OY +2 more
europepmc +1 more source
China's Low‐Carbon Energy Transition Over the Past Two Decades: Experiences and Implications
Advanced Science, EarlyView.China's low‐carbon energy transition features a brief decline and subsequent rebound in coal consumption, alongside the rapid expansion of renewable energy. This study develops a stage‐based analytical framework to explain this evolution from the perspectives of economic development, energy security, and environmental sustainability, revealing how ...
Yu Liu +3 more
wiley +1 more source
Conflict-Related Disruption of Oncology Drug Supply in the Gulf and Measures to Maintain Cancer Care Continuity. [PDF]
Glob J Qual Saf HealthcAbusanad A, Esba LCA, Kullab S.
europepmc +1 more source
Advanced Science, EarlyView.The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li +6 more
wiley +1 more source