Results 111 to 120 of about 4,060,865 (318)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Optimization of Watt's Six-bar Linkage to Generate Straight and Parallel Leg Motion
International Journal of Advanced Robotic Systems, 2008 This paper considers optimal synthesis of a special type of four-bar linkages. Combination of this optimal four-bar linkage with on of it's cognates and elimination of two redundant cognates will result in a Watt's six-bar mechanism, which generates ...
Saeed Akbarnejad, Hamid Mehdigholi
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Design and Research Co-Simulation Platform of Navigation and Dynamics on Planetary Rovers
Xibei Gongye Daxue Xuebao, 2019 The overall design idea of simulation platform of the planetary rover coupling navigation and dynamics is proposed to address the dilemma faced in the design of a navigation control system for Mars and other planetary exploration tasks.
doaj +1 more source
A web application to perform linkage disequilibrium and linkage analyses on a computational grid
, 2009 Motivation: Unravelling the genetic architecture of complex traits requires large amounts of data, sophisticated models and large computational resources.
Hernandez Sanchez, Julio +2 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Public attitudes to data linkage and sharing [PDF]
, 2016 ObjectiveTo capture a baseline of public attitudes in Northern Ireland towards data linkage and sharing which can then be reassessed at intervals to measure changes in public trust and understanding.
Dowds, Lizanne +5 more
core +4 more sources
International comparison in walkable environments and hospital burden in type 2 diabetes patients
International Journal of Population Data Science, 2018 Introduction While some comparative work has provided evidence for a universally positive impact of built environment features that promote physical activity, less is known about chronic diseases and hospitalization among different social contexts and ...
Sarah M Mah +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Efficient Sequential and Parallel Algorithms for Incremental Record Linkage
, 2019 In the biomedical domain, the record linkage is considered as a crucial problem. When the number of records is very large, existing algorithms for record linkage take too much time.
Baihan, Abdullah
core +1 more source