Results 41 to 50 of about 2,078,766 (244)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Nonconvex Implementation of Sparse Subspace Clustering: Algorithm and Convergence Analysis

IEEE Access, 2020
Subspace clustering has been widely applied to detect meaningful clusters in high-dimensional data spaces. And the sparse subspace clustering (SSC) obtains superior clustering performance by solving a relaxed ℓ0-minimization problem with ℓ1-
Xiaoge Deng, Tao Sun, Peibing Du, Dongsheng Li   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Large-Scale Heterogeneous Computing for 3D Deterministic Particle Transport on Tianhe-2A Supercomputer

Frontiers in Energy Research, 2021
Scalable parallel algorithm for particle transport is one of the main application fields in high-performance computing. Discrete ordinate method (Sn) is one of the most popular deterministic numerical methods for solving particle transport equations.
Biao Li, Biao Li, Jie Liu, Jie Liu, Xiaoxiong Zhu, Xiaoxiong Zhu, Shengjie Ding, Shengjie Ding   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Experimental Demonstration Of The Fixed-Point Sparse Coding Performance

Cybernetics and Information Technologies, 2014
The Sparse Coding (SC) model has been proved to be among the best neural networks which are mainly used in unsupervised feature learning for many applications.
Jiang Jingfei, Hu Rongdong, Zhang Fei, Dou Yong   +3 more
doaj   +1 more source

Another Robust NMF: Rethinking the Hyperbolic Tangent Function and Locality Constraint

IEEE Access, 2019
Non-negative matrix factorization (NMF) is a classical data analysis tool for clustering tasks. It usually considers the squared loss to measure the reconstruction error, thus it is sensitive to the presence of outliers. Looking into the literature, most
Xingyu Shen, Xiang Zhang, Long Lan, Qing Liao, Zhigang Luo   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Hypergraph Modeling and Approximation Algorithms for the Minimum Length Link Scheduling in Multiuser MIMO Networks

Journal of Applied Mathematics, 2013
This paper investigates the problem of the minimum length link scheduling (MLLS) in multiuser MIMO (MU-MIMO) networks. Generally, in the networks with MU-MIMO capability, the number of concurrent transmissions can be as large as that of antenna elements ...
Hu Shen, Shaohe Lv, Xuan Dong, Junquan Deng, Xiaodong Wang, Xingming Zhou   +5 more
doaj   +1 more source