Results 121 to 130 of about 1,785,585 (297)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Local habitat restoration in streams: Constraints on the effectiveness of restoration for stream biota

, 2003
The restoration of physical habitat has emerged as a key activity for managers charged with reversing the damage done by humans to streams and rivers, and there has been a great expenditure of time, money and other resources on habitat restoration ...
Lake, P., Lake, PS, Bond, NR, Bond, N.
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Agglomerative Hierarchical Clustering Methodology to Restore Power System considering Reactive Power Balance and Stability Factor Analysis

International Transactions on Electrical Energy Systems
Despite there are significant advancements in modern power systems, blackouts remain a potential risk, necessitating efficient restoration strategies. This paper introduces an innovative concept for power system restoration, focusing on balancing active ...
Srijan Khadka, Abhishek Wagle, Bibek Dhakal, Rupesh Gautam, Tajana Nepal, Ashish Shrestha, Francisco Gonzalez-Longatt   +6 more
doaj   +1 more source

Other title: Statehouse preservation and restoration Other title: Capitol Restoration Commission presentation Other title: Presentation

, 2005
Cover title.; "December 19, 2005."Agenda overview -- Design and construction update -- Project timeline, project budget and scope of work -- Construction sequencing of work -- Floor plans, updated 17 November 2004 -- Appendix: Project roles and ...
Kansas. Capitol Restoration Commission.
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Other title: Statehouse preservation and restoration Other title: Capitol Restoration Commission presentation Other title: Presentation

, 2006
Title from cover.; "December 14, 2006."Agenda overview and introductions -- Building design, architecture update -- Construction update -- Floor plans, sequence of construction -- Timeline, budget, funding phases -- Appendix: project roles ...
Kansas. Capitol Restoration Commission.
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Other title: Statehouse preservation and restoration Other title: Capitol Restoration Commission presentation Other title: Presentation

, 2004
Cover title.; "November 17, 2004."Agenda overview -- Design and construction update -- Project timeline, project budget and scope of work -- Construction sequencing of work -- Appendix: Project roles and ...
Kansas. Capitol Restoration Commission.
core