Recent Advances in the Pathogenesis and Drug Action in Periodic Paralyses and Related Channelopathies [PDF]
, 2011 The periodic paralysis (PP) are rare autosomal-dominant disorders associated to mutations in the skeletal muscle sodium, calcium, and potassium channel genes characterized by muscle fiber depolarization with un-excitability, episodes of weakness with ...
Camerino, Diana Conte +1 more
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Hypokalaemic periodic paralysis in patients presenting with severe limb paralysis at PUMHSW Nawabshah [PDF]
, 2021 Objective: To determine the hypokalemic periodic paralysis rate in patients presenting with severe limb paralysis at PUMHSW Nawabshah. Methodology: This descriptive was conducted Medical department of Peoples Medical College & hospital Nawabshah from
Abdul Aziz Sahito +5 more
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Acetazolamide opens the muscular K(Ca)2+ channel: A novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis [PDF]
, 2000 Acetazolamide is a thiazide derivative clinically used in skeletal muscle disorders related to altered K+ homeostasis such as the periodic paralyses. The mechanism of action responsible for the therapeutic effects of the drug is still unknown, however ...
Barbieri, Mariagrazia +2 more
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Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). [PDF]
, 2001 Voltage-gated potassium channels provide tightly Controlled, ion-specific pathways across membranes and are key to the normal function of nerves muscles. They arise from the assembly of four pore-forming proteins called alpha-subunits.
Abbott, GW, Goldstein, SA
core
Periodic paralysis with generalized epilepsy in a Nigerian child: A case report [PDF]
, 2018 The periodic paralyses are a rare group of muscle channel opathies characterized by intermittent attacks of episodic muscle weakness of variable duration. Typically, symptoms begin in the first or second decade of life.
Imoudu, IA
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Advanced Materials, EarlyView.The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li +19 more
wiley +1 more source
Practical aspects in the management of hypokalemic periodic paralysis [PDF]
, 2008 Management considerations in hypokalemic periodic paralysis include accurate diagnosis, potassium dosage for acute attacks, choice of diuretic for prophylaxis, identification of triggers, creating a safe physical environment, peri-operative measures, and
BD Rose +20 more
core +3 more sources
Multi‐Material Additive Manufacturing of Soft Robotic Systems: A Comprehensive Review
Advanced Robotics Research, EarlyView.This review explores the transformative role of multi‐material additive manufacturing (MMAM) in the development of soft robotic systems. It presents current techniques, materials, and design strategies that enable functionally graded and adaptive structures.
Ritik Raj +2 more
wiley +1 more source
Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. [PDF]
, 2019 Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability.
Cannon, Stephen C +4 more
core +1 more source
Definitions, 2020 A group of genetic neurological disorders caused by mutations in genes involved in the sodium and calcium channels in nerve cells. It is characterized by episodes of muscle paralysis in which the affected muscles become flaccid and the deep tendon ...
semanticscholar +1 more source