Results 121 to 130 of about 281,357 (305)

IC100 blocks inflammasome activation induced by α-synuclein aggregates and ASC specks

npj Parkinson's Disease
Parkinson’s disease (PD) is associated with chronic sterile inflammation and persistent inflammasome activation involving α-synuclein and ASC protein aggregates, but the underlying mechanisms of the neuroinflammatory response remain unclear.
Brianna Cyr, Regina T. Vontell, Roey Hadad, Juan Pablo de Rivero Vaccari, Robert W. Keane   +4 more
doaj   +1 more source

‘Turkeys Cannot Vote for Christmas’: Why Epistemic Disobedience in an Anti‐Black World Matters

Australian Journal of Social Issues, EarlyView.
ABSTRACT Never in the history of global coloniality has the idea of epistemic disobedience been as important as in the 21st century. This is not only because the struggle for decolonisation has shifted from physical confrontation between the coloniser and the colonised into a battle of ideas but also because the former has deployed the idea of ...
Morgan Ndlovu
wiley   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology

Molecular Systems Biology, 2010
Development and regeneration of the nervous system requires the precise formation of axons and dendrites. Kinases and phosphatases are pervasive regulators of cellular function and have been implicated in controlling axodendritic development and ...
William J Buchser, Tatiana I Slepak, Omar Gutierrez‐Arenas, John L Bixby, Vance P Lemmon   +4 more
doaj   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Significant Clinical Improvements Following Arthroscopic Iliopsoas Fractional Lengthening After Total Hip Arthroplasty: A Prospective Multicenter Study

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To prospectively investigate subjective anterior groin pain, patient‐reported outcome measures, complications, reoperation rates, and hip flexion strength after arthroscopic iliopsoas fractional lengthening. Methods From 2023 to 2025, patients with persistent groin pain after total hip arthroplasty refractory to conservative management ...
Brandon Cabarcas, Sanathan Iyer, Sandeep Yanamala, Jason Ina, Alexander Bishop, Adam V. Daniel, Bruce A. Levy, Mario Hevesi   +7 more
wiley   +1 more source

Treatment of Developmental Dysplasia of the Acetabulum by Hip Arthroscopic Acetabuloplasty Combined With Labral Repair, Cam and Pincer Osteoplasty, Collagen‐Induced Autologous Chondroplasty, and Capsule Suture

Arthroscopy Techniques, EarlyView.
Abstract Developmental hip dysplasia due to insufficient acetabular coverage and excessive pressure on the femoral head can easily lead to labral tears, damage to the labrum–cartilage junction, cam and pincer deformities, and joint capsule laxity. This may ultimately result in osteoarthritis.
Dongdong Zhou, Jin Zhang, Zhe Xue, Zhengwei Zhu, Shihao Yang, Deding Liu, Xinyue Zhang, Ceyong Sun   +7 more
wiley   +1 more source

Facial nerve paralysis and partial brachial plexopathy after epidural blood patch: a case report and review of the literature

, 2011
Radi Shahien, Abdalla BowirratDepartment of Neurology, Ziv Medical Center, Zfat, IsraelAbstract: We report a complication related to epidural analgesia for delivery in a 24-year-old woman who was admitted with mild pre-eclampsia and for induction of ...
Radi Shahien, Abdalla Bowirrat, Shahien Radi   +2 more
core   +1 more source

Acute infection of bees with paralysis virus

, 1964
Acute bee paralysis virus (ABPV) occurs commonly in adult honey bees (Apis mellifera Linnaeus) in Britain. The amount of the virus in different bees differs, as does the proportion of infected bees in different colonies.
Gibbs, J., Bailey, L.
core  

Arthroscopic Superior Capsule Reconstruction Using Hamstring Allograft in V‐Shaped Configuration

Arthroscopy Techniques, EarlyView.
Abstract Massive irreparable rotator cuff tears remain a challenge for the orthopaedic surgeon a great spectrum from conservative to surgical procedures have been described. Superior capsular reconstruction is an option in active young patients with massive irreparable rotator cuff tears without arthritis, which reduce the humeral head superior ...
Hernando Canal Torres, Valeria Latorre Jaramillo, Luis Alfredo Moreno, Rodrigo Lopez, Gustavo Chavarro, Ricardo González, Fabio Restrepo   +6 more
wiley   +1 more source