Results 221 to 230 of about 546,753 (389)

Mapping Glial Autophagy Dynamics in an Amyotrophic Lateral Sclerosis Mouse Model Reveals Microglia and Astrocyte Autophagy Dysfunction

open access: yesGlia, EarlyView.
In SOD1 mice, symptomatic spinal microglia and astrocytes show increased autophagy flux with greater dysfunction and SOD1 inclusions in astrocytes. Dysfunction was transient (end stage glia displayed control comparable levels of autophagy parameters). ABSTRACT Amyotrophic lateral sclerosis (ALS) is defined by motor neuron death.
Nirma D. Perera   +4 more
wiley   +1 more source

Investigating the Spillover Mechanisms of Payment Incentives on the Outcomes for Non‐Targeted Patients

open access: yesHealth Economics, EarlyView.
ABSTRACT Payment reforms in healthcare can have spillover effects on the care experienced by non‐targeted patients treated by the same provider. Few empirical studies have quantitatively investigated the mechanisms behind these effects. We formulate theory‐driven hypotheses to investigate the spillover mechanisms of a regional payment reform in the ...
Philip Britteon   +4 more
wiley   +1 more source

Conversion Surgery After Administration of a TRK Inhibitor for Unresectable Parotid Gland Secretory Carcinoma

open access: yesHead &Neck, EarlyView.
ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Arisa Nagano   +11 more
wiley   +1 more source

EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain

open access: yesNeurobiology of Disease, 2016
Traumatic brain injury (TBI), ranging from mild concussion to severe penetrating wounds, can involve brain regions that contain damaged or lost synapses in the absence of neuronal death.
Enmanuel J. Perez   +5 more
doaj  

Median effective dosage of midazolam oral solution for preschool children in preoperative sedation

open access: yesIbrain, EarlyView.
This study aimed to detect median effective dosage (ED50) of midazolam oral solution (MOS) for preschool children in preoperative sedation. Thirty children who were scheduled for elective of the hidden penis correction surgery under general anesthesia in the pediatric surgery department were selected.
Rui Jiang   +5 more
wiley   +1 more source

Severe relapse after cessation of immunosuppressive therapy in a patient with co‐occurrence of neuromyelitis optica spectrum disorder and Sjögren's syndrome: A case report

open access: yesIbrain, EarlyView.
We report a girl with a diagnosis of “neuromyelitis optica spectrum disorder comorbid Sjogren's syndrome” whose condition showed significant improvement after treatment with corticosteroids and immunosuppressive drugs (prednisolone, hydroxychloroquine, and mycophenolate mofetil).
Man‐Min Zhu   +3 more
wiley   +1 more source

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