Results 131 to 140 of about 3,476,396 (288)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Parameter estimation for a computable general equilibrium model: a maximum entropy approach [PDF]

open access: yes
We introduce a maximum entropy approach to parameter estimation for computable general equilibrium (CGE) models. The approach applies information theory to estimating a system of nonlinear simultaneous equations. It has a number of advantages.
Tarp, Finn   +2 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

A Half-Discrete Mulholland-Type Inequality Involving One Multiple Upper Limit Function

open access: yesAxioms
In this paper, by means of weight coefficient methods and the Euler–Maclaurin summation formula, a half-discrete Mulholland-type inequality involving one multiple upper limit function is established, with the kernel (x+nβ)−λ (λ > 0, β ∈ (0, 1]).
Xianchun Meng   +3 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Classification Algorithm for Linearly Inseparable Datasets Based on SMC Strategy

open access: yesZhengzhou Daxue xuebao. Gongxue ban
For the classification problem of linearly inseparable datasets, a support vector machine (SVM) kernel function parameter optimization algorithm was proposed based on the sliding mode control (SMC) strategy by applying the SMC idea to the SVM kernel ...
ZHANG Guangchen   +3 more
doaj   +1 more source

Distributions of Functionals of the two Parameter Poisson-Dirichlet Process [PDF]

open access: yes
The present paper provides exact expressions for the probability distribution of linear functionals of the two–parameter Poisson–Dirichlet process. Distributional results that follow from the application of an inversion formula for a (generalized) Cauchy–
Antonio Lijoi   +2 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Superconductivity of various borides: The role of stretched c-parameter

open access: yes, 2009
The superconductivity of MgB2, AlB2, NbB2+x, and TaB2+x is intercompared. The stretched c-lattice parameter (c = 3.52 Å) of MgB2 in comparison to NbB2.4 (c = 3.32 Å) and AlB2 (c = 3.25 Å) decides empirically the population of their π and σ bands and as a
G L Bhalla (20222406)   +5 more
core  

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