Results 181 to 190 of about 7,189,567 (273)

An Accurate Alternative to Hybrid Functionals for Germanium: DFT+α. [PDF]

J Phys Chem C Nanomater Interfaces
Abdurrazaq A, Lot R, Jay A, Herrero-Saboya G, Richard N, Martin-Samos L, Hémeryck A, de Gironcoli S.   +7 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Wavelet-Based Denoising Optimization for Endoscopic Gastric Slow-Wave Recordings. [PDF]

Healthc Technol Lett
Tremain P, Dowrick JM, Cheng LK, McKeage JW, Saavedra C, Sotelo J, Angeli-Gordon TR.   +6 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Mathematical analysis of metronomic chemotherapy response in metastatic gastrointestinal cancer: identifying critical parameters from clinical data. [PDF]

Sci Rep
Manca ML, Michelangeli A, Bocci G, Orlandi P, Allegrini G, Kirken RA, Francia G, Georgiev V.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The stability of IRT parameters under several test equating conditions. [PDF]

Front Psychol
Weber D, Becker N, Spinath FM, Koch M.
europepmc   +1 more source

Parameters

For the planets expected to be analysed in WP2: prediction of the evolution of the orbital state and consequences for planetary climates. Estimate of the total energy budget: insolation and tidal heating. Estimate of the atmospheric mass loss from the planet. Range of atmospheric/surface temperature of planets from Global Climate Models.
openaire   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A hierarchical framework to evaluate the usability of smartphone health applications. [PDF]

Sci Rep
Siddique A, Sajjad Q, Algamdi SA, Shahzad B, Hussien JM.   +4 more
europepmc   +1 more source