Results 91 to 100 of about 675,051 (266)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

On the parameter selection of randomness test

open access: yesTongxin xuebao, 2009
The conditions that two different parameters in a same randomness test should satisfy if they are independ- ent with each other was studied based on statistical theory.
FAN Li-min1, FENG Deng-guo1, CHEN Hua1
doaj  

Research on Mobile Robot Path Planning Based on MSIAR-GWO Algorithm

open access: yesSensors
Path planning is of great research significance as it is key to affecting the efficiency and safety of mobile robot autonomous navigation task execution. The traditional gray wolf optimization algorithm is widely used in the field of path planning due to
Danfeng Chen   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Study on the Impact of Input Parameters on Seawater Dissolved Oxygen Prediction Models

open access: yesJournal of Marine Science and Engineering
The concentration of dissolved oxygen (DO) in seawater is a core ecological indicator in aquaculture, and its accurate prediction is of great value for the management of marine ranching.
Wenqing Li   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Robust and Simple ADMM Penalty Parameter Selection

open access: yesIEEE Open Journal of Signal Processing
We present a new method for online selection of the penalty parameter for the alternating direction method of multipliers (ADMM) algorithm. ADMM is a widely used method for solving a range of optimization problems, including those that arise in signal ...
MICHAEL T. MCCANN, Brendt Wohlberg
doaj   +1 more source

Selection of Reconstruction Parameters

open access: yes, 2015
This report reviews the theory of radiometer image formation and reconstruction. It presents simulation results used to select the nominal pixel size and reconstruction algorithms for the Calibrated Passive Microwave Daily EASE-Grid 2.0 Brightness Temperature ESDR (CETB).
openaire   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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