Results 111 to 120 of about 36,337,967 (229)

Compressed Linear Genetic Programming: Empirical

open access: yes, 2008
Modularisation is of intrest to the EA community as a mechanism to allow evolution to address larger problems. Starting from basic elements modularisation could make it possible to reuse higher level functionalities discovered during the evolutionary ...
Parameter Study On
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Parameter study with varying regularization parameter λreg during polarized cell motility.

open access: yes
Parameter study with varying regularization parameter λreg during polarized cell motility.
Wilhelm Huisinga (226681)   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Parameter-Free Search of Time-Series Discord

open access: yes, 2013
Parameter-Free Search of Time-Series ...
Wei Luo (13099695)   +2 more
core  

Parameter study with varying regularization parameter λreg during non-polarized cell motility.

open access: yes
Parameter study with varying regularization parameter λreg during non-polarized cell motility.
Wilhelm Huisinga (226681)   +4 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

StudyonParameterMulti-objectiveCalibrationandParameterCombinationForecastof ConceptualHydrologicalModel

open access: yes工程科学与技术, 2014
:To obtain a successful parameter calibration of conceptual hydrological model,hydrological characteristics of large and small runoff process were chosen for considering different characteristics of generation and concentration.A multi-objective cultural
欧阳硕   +3 more
doaj  

Parameter Study on Friction Surfacing of AISI316Ti Stainless Steel over EN8 Carbon Steel and Its Effect on Coating Dimensions and Bond Strength. [PDF]

open access: yesMaterials (Basel), 2021
Rethnam GSN   +7 more
europepmc   +1 more source

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