Results 81 to 90 of about 18,691 (261)

Practical Access to Dynamic Programming on Tree Decompositions

Algorithms, 2019
Parameterized complexity theory has led to a wide range of algorithmic breakthroughs within the last few decades, but the practicability of these methods for real-world problems is still not well understood.
Max Bannach, Sebastian Berndt
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Vacancy‐Suppressed Garnet Electrolytes for Durable Solid‐State Batteries

Advanced Science, EarlyView.
A Li/O‐rich sintering strategy effectively suppresses intrinsic lithium and oxygen vacancies in cubic garnet electrolytes, yielding a dense and stable microstructure. The vacancy‐controlled electrolyte exhibits enhanced interfacial and air stability, enabling long‐term solid‐state battery cycling and providing a general design principle for defect ...
Seokjae Hong, Kwang Ho Shin, Kyoung Sun Kim, Jinhwan Kim, Jaegi Lee, Byung‐Gun Park, Won G. Hong, In Hye Kwak, Kyubin Shim, Young‐Sang Yu, Ju Young Kim, Young Hwa Jung, Min Wook Pin, Hyeon‐Jong Lee, Hojoon Kim, Dong‐Hwa Seo, Hosun Shin, Dongju Lee, Seung‐Ho Yu, Sung‐Kyun Jung, Hyungsub Kim   +20 more
wiley   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Characterizing quantum codes via the coefficients in Knill-Laflamme conditions

npj Quantum Information
Quantum error correction (QEC) is essential for protecting quantum information against noise, yet understanding the structure of the Knill-Laflamme (KL) coefficients $$\left\{{\lambda }_{ij}\right\}$$ λ i j from the condition $$P{E}_{i}^{\dagger }{E}_{j ...
Mengxin Du, Chao Zhang, Yiu Tung Poon, Bei Zeng   +3 more
doaj   +1 more source

EmbodiedCoder: Parameterized Embodied Mobile Manipulation via Modern Coding Model

Demo Page: https://embodiedcoder.github.io/EmbodiedCoder/
Lin, Zefu, Cui, Rongxu, Hanning, Chen, Wang, Xiangyu, Xu, Junjia, Jin, Xiaojuan, Wenbo, Chen, Zhou, Hui, Fan, Lue, Li, Wenling, Zhang, Zhaoxiang   +10 more
openaire   +2 more sources

Smart Optogenetics for Real‐Time Automated Control of Cardiac Electrical Activity

Advanced Science, EarlyView.
We are able to stop dangerous heart‐rhythm spirals before they fully form. Within about 100 ms, it pinpoints the spiral's tiny central tip (≈0.9 mm) using light‐based sensing and machine learning, then shines targeted light to shut it down. This fast, precise, closed‐loop approach detects, targets, and terminates arrhythmias in real time.
Shanliang Deng, Niels Harlaar, Juan Zhang, Sven O. Dekker, Nina N. Kudryashova, Huiling Zhou, Cindy I. Bart, TianYi Jin, Georgy Derevyanko, Willem van Driel, Alexander V. Panfilov, René H. Poelma, Antoine A. F. de Vries, GuoQi Zhang, Tim De Coster, Daniël A. Pijnappels   +15 more
wiley   +1 more source

On Parameterized Gallager's First Bounds for Binary Linear Codes over AWGN Channels

, 2012
In this paper, nested Gallager regions with a single parameter is introduced to exploit Gallager's first bounding technique (GFBT). We present a necessary and sufficient condition on the optimal parameter. We also present a sufficient condition (with a simple geometrical explanation) under which the optimal parameter does not depend on the signal-to ...
Ma, Xiao, Liu, Jia, Bai, Baoming
openaire   +2 more sources

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Photonuclear Population of 229m,gTh in Th‐Doped Crystals Toward Nuclear Clock Development

Advanced Science, EarlyView.
This study demonstrates a novel photonuclear approach for producing the nuclear clock isomer 229mTh in thorium‐doped crystals, overcoming current supply limitations. Through cross‐section calculations and Monte Carlo simulations, we identify optimal crystal materials and irradiation conditions, achieving high signal‐to‐noise ratios.
Hao‐Yang Lan, Di Wu, Mei‐Zhi Wang, Zhong‐Yi Chen, Jian‐Feng Lv, Yu‐Hui Xia, Zhe‐Nan Wang, Wen Luo, Xin‐Lu Xu, Xue‐Qing Yan   +9 more
wiley   +1 more source