Results 161 to 170 of about 147,152 (326)

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen   +11 more
wiley   +1 more source

Parameterized Complexity of Feedback Vertex Sets on Hypergraphs

open access: green, 2020
Pratibha Choudhary   +4 more
openalex   +2 more sources

EasyAmplicon 2: Expanding PacBio and Nanopore Long Amplicon Sequencing Analysis Pipeline for Microbiome

open access: yesAdvanced Science, EarlyView.
EasyAmplicon 2 is an updated, user‐friendly, and community‐supported pipeline designed for full‐length amplicon data from long‐read sequencing technologies such as PacBio and Nanopore. It supports multiple platforms (Illumina, PacBio, Nanopore, etc.), integrates tools like DADA2 and Emu, and offers a complete workflow from raw data processing to high ...
Hao Luo   +24 more
wiley   +1 more source

Explaining Decisions in ML Models: a Parameterized Complexity Analysis (Part I) [PDF]

open access: green
Sebastian Ordyniak   +3 more
openalex   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

open access: yesAdvanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu   +8 more
wiley   +1 more source

Puerarin Targets MIC19 to Suppress Mitochondrial Metabolism of Tumor‐Infiltrating Tregs and Enhance Anti‐tumor Immunity

open access: yesAdvanced Science, EarlyView.
Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li   +10 more
wiley   +1 more source

Stabilizing Stretchable Organic Transistors Through Small‐Molecule Additive Blending for Ultra‐Sensitive Pesticide Detection

open access: yesAdvanced Science, EarlyView.
This study introduces a small‐molecule additive to improve the stability of stretchable organic field‐effect transistor (OFET). Furthermore, stretchable OFET‐based pesticide sensors with extended‐gate electrodes are constructed. It achieves highly sensitive and precise detection of chlorpyrifos pesticide, reaching a detection limit as low as 0.032 ppb.
Weiyu Wang   +9 more
wiley   +1 more source

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